12 Result(s)
within
English
Bioinformatics
Jian-** Cao
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Article
Open AccessHierarchical modularity of nested bow-ties in metabolic networks
The exploration of the structural topology and the organizing principles of genome-based large-scale metabolic networks is essential for studying possible relations between structure and functionality of metab...
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Article
Open AccessModular co-evolution of metabolic networks
The architecture of biological networks has been reported to exhibit high level of modularity, and to some extent, topological modules of networks overlap with known functional modules. However, how the modula...
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The mechanisms and possible significance of upregulation of stomatin expression by hypoxia and/or glucocorticoids
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Article
Open AccessGenome sequence of foxtail millet (Setaria italica) provides insights into grass evolution and biofuel potential
Completion of genome sequences for the diploid Setaria italica reveals features of C4 photosynthesis that could enable improvement of the polyploid biofuel crop switchgrass (Panicum virgatum). The genetic basis o...
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Open AccessSequencing of allotetraploid cotton (Gossypium hirsutum L. acc. TM-1) provides a resource for fiber improvement
Two draft sequences of Gossypium hirsutum, the most widely cultivated cotton species, provide insights into genome structure, genome rearrangement, gene evolution and cotton fiber biology.
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Article
Open AccessBMCMDA: a novel model for predicting human microbe-disease associations via binary matrix completion
Human Microbiome Project reveals the significant mutualistic influence between human body and microbes living in it. Such an influence lead to an interesting phenomenon that many noninfectious diseases are clo...
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Open AccessFOXC1-mediated LINC00301 facilitates tumor progression and triggers an immune-suppressing microenvironment in non-small cell lung cancer by regulating the HIF1α pathway
Long non-coding RNAs (lncRNAs) are extensively intricate in the tumorigenesis and metastasis of various cancer types. Nevertheless, the detailed molecular mechanisms of lncRNA in non-small cell lung cancer (NS...
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Open AccessAn integrated peach genome structural variation map uncovers genes associated with fruit traits
Genome structural variations (SVs) have been associated with key traits in a wide range of agronomically important species; however, SV profiles of peach and their functional impacts remain largely unexplored.
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Open AccessIdentification of driver genes based on gene mutational effects and network centrality
As one of the deadliest diseases in the world, cancer is driven by a few somatic mutations that disrupt the normal growth of cells, and leads to abnormal proliferation and tumor development. The vast majority ...
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Open AccessDisruption of three polyamine uptake transporter genes in rice by CRISPR/Cas9 gene editing confers tolerance to herbicide paraquat
Weeds are a major biotic constraint that can cause dramatic crop production losses. Herbicide technology has been widely used by farmers as the most cost-effective weed control measure, and development of new ...
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Article
Open AccessFunctional differentiation determines the molecular basis of the symbiotic lifestyle of Ca. Nanohaloarchaeota
Candidatus Nanohaloarchaeota, an archaeal phylum within the DPANN superphylum, is characterized by limited metabolic capabilities and limited phylogenetic diversity and until recently has been considered to exclu...
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Article
Open AccessGut microbiota-derived LCA mediates the protective effect of PEDV infection in piglets
The gut microbiota is a critical factor in the regulation of host health, but the relationship between the differential resistance of hosts to pathogens and the interaction of gut microbes is not yet clear. He...
