12 Result(s)
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Open AccessThe mutation rate of rpoB gene showed an upward trend with the increase of MIRU10, MIRU39 and QUB4156 repetitive number
Mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) is a frequently used ty** method for identifying the Bei**g genotype of Mycobacterium tuberculosis (Mtb), which is easily tr...
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Open AccessIntegrative analysis of transcriptomics and metabolomics to reveal the melanogenesis pathway of muscle and related meat characters in Wuliangshan black-boned chickens
Melanin is an important antioxidant in food and has been used in medicine and cosmetology. Chicken meat with high melanin content from black-boned chickens have been considered a high nutritious food with pote...
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Open AccessIdentification of driver genes based on gene mutational effects and network centrality
As one of the deadliest diseases in the world, cancer is driven by a few somatic mutations that disrupt the normal growth of cells, and leads to abnormal proliferation and tumor development. The vast majority ...
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Open AccessExpression characteristics of pineal miRNAs at ovine different reproductive stages and the identification of miRNAs targeting the AANAT gene
Many recent studies have shown that miRNAs play important roles in the regulation of animal reproduction, including seasonal reproduction. The pineal gland is a crucial hub in the regulation of seasonal reprod...
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Open AccessGenome of the webworm Hyphantria cunea unveils genetic adaptations supporting its rapid invasion and spread
The fall webworm Hyphantria cunea is an invasive and polyphagous defoliator pest that feeds on nearly any type of deciduous tree worldwide. The silk web of H. cunea aids its aggregating behavior, provides thermal...
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Open AccessGenetic boundaries delineate the potential human pathogen Salmonella bongori into discrete lineages: divergence and speciation
Salmonella bongori infect mainly cold-blooded hosts, but infections by S. bongori in warm-blooded hosts have been reported. We hypothesized that S. bongori might have diverged into distinct phylogenetic lineages,...
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Open AccessBMCMDA: a novel model for predicting human microbe-disease associations via binary matrix completion
Human Microbiome Project reveals the significant mutualistic influence between human body and microbes living in it. Such an influence lead to an interesting phenomenon that many noninfectious diseases are clo...
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Open AccessA chelicerate-specific burst of nonclassical Dscam diversity
The immunoglobulin (Ig) superfamily receptor Down syndrome cell adhesion molecule (Dscam) gene can generate tens of thousands of isoforms via alternative splicing, which is essential for both nervous and immune s...
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Open AccessGlobal transcriptome profiles of Camellia sinensis during cold acclimation
Tea is the most popular non-alcoholic health beverage in the world. The tea plant (Camellia sinensis (L.) O. Kuntze) needs to undergo a cold acclimation process to enhance its freezing tolerance in winter. Change...
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Open AccessCharacterization and differential expression of microRNAs in the ovaries of pregnant and non-pregnant goats (Capra hircus)
Ovarian follicular development and hormone secretion are complex and coordinated biological processes which will usually be altered during pregnancy. Ovarian function is tightly regulated by a multitude of gen...
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Open AccessModular co-evolution of metabolic networks
The architecture of biological networks has been reported to exhibit high level of modularity, and to some extent, topological modules of networks overlap with known functional modules. However, how the modula...
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Open AccessHierarchical modularity of nested bow-ties in metabolic networks
The exploration of the structural topology and the organizing principles of genome-based large-scale metabolic networks is essential for studying possible relations between structure and functionality of metab...
