62 Result(s)

Article

Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway

Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2’s role and the specific mechanism...

Mi Lin, Ru-Hong Tu, Sheng-Ze Wu, Qing Zhong, Kai Weng, Yu-Kai Wu… in Cell Death & Disease (2024)

Article

Author Correction: A genetically encoded ratiometric indicator for tryptophan

Rongkun Tao, Kui Wang, Tian-lun Chen, **n-xin Zhang, Jian-bin Cao… in Cell Discovery (2024)

Article

Author Correction: Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-**n Yang, Zhen-Zhen Ma, Lin Huang… in Cell Discovery (2024)

Article

Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model

Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...

Yang Fu, Yong-Song Chen, Dai-Yang **a, **ao-Dan Luo… in npj Biofilms and Microbiomes (2024)

Article

LncRNA LUESCC promotes esophageal squamous cell carcinoma by targeting the miR-6785-5p/NRSN2 axis

Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent gastrointestinal malignancies with high mortality worldwide. Emerging evidence indicates that long noncoding RNAs (lncRNAs) are involved i...

Song-tao Xue, Shi-qiang Cao, Jian-cheng Ding… in Cellular and Molecular Life Sciences (2024)

Article

PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells

Maintaining genomic stability is a prerequisite for proliferating NPCs to ensure genetic fidelity. Though histone arginine methylation has been shown to play important roles in safeguarding genomic stability, ...

Ya-Jun Wang, Jian-Bo Cao, **g Yang, Tong Liu… in Cellular and Molecular Life Sciences (2024)

Article

CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma

The oncogenic role of circRNA in cancers including esophageal cancer (EC) has been well studied. However, whether and how circRNAs are involved in cancer cell metabolic processes remains largely unknown. Here,...

Shi-qiang Cao, Song-tao Xue, Wen-juan Li, Guo-sheng Hu, Zhi-gang Wu… in Cell Death Discovery (2024)

Article

Endothelial extracellular vesicles induce acute lung injury via follistatin-like protein 1

Cardiopulmonary bypass has been speculated to elicit systemic inflammation to initiate acute lung injury (ALI), including acute respiratory distress syndrome (ARDS), in patients after cardiac surgery. We previ...

Hao-**ang Yuan, Ya-Ting Chen, Yu-Quan Li, Yan-Sheng Wang… in Science China Life Sciences (2024)

Article

Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Ketogenic diet (KD) alleviates refractory epilepsy and reduces seizures in children. However, the metabolic/cell biologic mechanisms by which the KD exerts its antiepileptic efficacy remain elusive. Herein, we...

Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-**n Yang, Zhen-Zhen Ma, Lin Huang… in Cell Discovery (2024)

Article

Mitochondrial genomes provide insights into the Euholognatha (Insecta: Plecoptera)

Euholognatha is a monophyletic group within stoneflies comprised by a superfamily Nemouroidea and a family Scopuridae. Based on morphological data, the family-level phylogenetic relationships within Euholognat...

**-Jun Cao, Ying Wang, Dávid Murányi, Jian-**n Cui… in BMC Ecology and Evolution (2024)

Article

CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma

Abnormal expression of Cylindromatosis (CYLD), a tumor suppressor molecule, plays an important role in tumor development and treatment. In this work, we found that CYLD binds to class I histone deacetylases (H...

Yueshuo Li, Chenxing Yang, Longlong **e, Feng Shi, Min Tang… in Cell Death & Disease (2024)

Article

Integrating genomic and multiomic data for Angelica sinensis provides insights into the evolution and biosynthesis of pharmaceutically bioactive compounds

Angelica sinensis roots (Angelica roots) are rich in many bioactive compounds, including phthalides, coumarins, lignans, and terpenoids. However, the molecular bases for their biosynthesis are still poorly unders...

Shiming Li, Tsan-Yu Chiu, **n **, Dong Cao, Meng Xu, Mingzhi Zhu… in Communications Biology (2023)

Article

RBMS3-induced circHECTD1 encoded a novel protein to suppress the vasculogenic mimicry formation in glioblastoma multiforme

Glioblastoma multiforme (GBM) is a highly vascularized malignant cancer of the central nervous system, and the presence of vasculogenic mimicry (VM) severely limits the effectiveness of anti-vascular therapy. ...

Xuelei Ruan, Yunhui Liu, ** Wang, Libo Liu, Teng Ma, Yixue Xue… in Cell Death & Disease (2023)

Article

Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in co...

Yu-Qing Wu, Chen-Song Zhang, **ye **ong, Dong-Qi Cai, Chen-Zhe Wang… in Cell Research (2023)

Article

A genetically encoded ratiometric indicator for tryptophan

Rongkun Tao, Kui Wang, Tian-lun Chen, **n-xin Zhang, Jian-bin Cao… in Cell Discovery (2023)

Article

DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway

CDK4/6 are important regulators of cell cycle and their inhibitors have been approved as anti-cancer drugs. Here, we report a STING-dependent anti-tumor immune mechanism responsible for tumor suppression by CD...

Huimin Fan, Wancheng Liu, Yanqiong Zeng, Ying Zhou, Meiling Gao… in Communications Biology (2023)

Article

Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury

The current study explores the potential function and the underlying mechanisms of endothelial cell-derived R-spondin 3 (RSPO3) neuroprotection against ischemia/reperfusion-induced neuronal cell injury. In bot...

Ting-tao Liu, **n Shi, Hong-wei Hu, Ju-** Chen, Qin Jiang… in Cell Death & Disease (2023)

Article

LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1

One of the characteristics of leukemia is that it contains multiple rearrangements of signal transduction genes and overexpression of non-mutant genes, such as transcription factors. As an important regulator ...

Lihui Lu, Jianwei Wang, Fang Fang, Ailian Guo, Shuting Jiang… in Cell Death & Disease (2023)

Article

Biomarkers of aging

Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...

Hainan Bao, Jiani Cao, Mengting Chen, Min Chen, Wei Chen… in Science China Life Sciences (2023)

Article

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Anillin (ANLN) is a mitosis-related protein that promotes contractile ring formation and cytokinesis, but its cell cycle-dependent degradation mechanisms in cancer cells remain unclear. Here, we show that high...

Yu-Fei Cao, Lei **e, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi… in Cell Death & Differentiation (2023)