24 Result(s)

Article

Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation

Intracellular accumulation of the hyperphosphorylated tau is a pathological hallmark in the brain of Alzheimer disease. Activation of extrasynaptic NMDA receptors (E-NMDARs) induces excitatory toxicity that is...

Xu-Ying Sun, Qing-Zhang Tuo, Zhen-Yu Liuyang, Ao-Ji **e… in Cell Death & Disease (2016)

Article

EIF3D promotes gallbladder cancer development by stabilizing GRK2 kinase and activating PI3K-AKT signaling pathway

Recent evidence suggests that dysregulated eIF3d expression may be critical in various genetic disorders as well as cancer. In this study, we observed that EIF3d levels increased in gallbladder cancer (GBC) sa...

Fei Zhang, Shanshan **ang, Yang Cao, Maolan Li, Qiang Ma… in Cell Death & Disease (2017)

Article

Ricolinostat (ACY-1215) suppresses proliferation and promotes apoptosis in esophageal squamous cell carcinoma via miR-30d/PI3K/AKT/mTOR and ERK pathways

Ricolinostat (ACY-1215), a first-in-class selective HDAC6 inhibitor, exhibits antitumor effects alone or in combination with other drugs in various cancers. However, its efficacy in esophageal cancer remains u...

**lin Cao, Wang Lv, Luming Wang, **ming Xu, ** Yuan, Sha Huang… in Cell Death & Disease (2018)

Article

Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy

Parkin and PINK1 play an important role in mitochondrial quality control, whose malfunction may also be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). Excessive TDP-43 accumulation is a p...

**ng Sun, Yongjia Duan, Caixia Qin, Jian-Chiuan Li, Gang Duan… in Cell Death & Disease (2018)

Article

Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer

Although TC2N has proven to be an oncogene in lung cancer, its biological function and molecular mechanisms in other cancer still remains unclear. Here, we investigate in breast cancer that TC2N expression is ...

**ang-lin Hao, Li-yun Gao, **ao-juan Deng, Fei Han, Hong-qiang Chen… in Cell Death & Disease (2019)

Article

Author Correction: Identification of TC2N as a novel promising suppressor of PI3K-AKT signaling in breast cancer

After publication of this article, it came to the attention of the authors that their names had been reordered. Professor. Jia Cao and Prof. **-yi Liu are the co-corresponding authors, and Prof. **-yi Liu sh...

**ang-lin Hao, Li-yun Gao, **ao-juan Deng, Fei Han, Hong-qiang Chen… in Cell Death & Disease (2019)

Article

Differentiation of human adipose-derived stem cells into neuron/motoneuron-like cells for cell replacement therapy of spinal cord injury

Human adipose-derived stem cells (hADSCs) are increasingly presumed to be a prospective stem cell source for cell replacement therapy in various degenerative and/or traumatic diseases. The potential of trans-d...

Shane Gao, Xuanxuan Guo, Simeng Zhao, Yinpeng **, Fei Zhou… in Cell Death & Disease (2019)

Article

PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-κB signaling pathway

Inflammatory factors and activation of oncogenes both played critical roles in the development and progression of human hepatocellular carcinoma (HCC). However, the interplay between these two has not been wel...

Xuming Tang, Tingting Cao, Yun Zhu, Liyi Zhang, **na Chen… in Cell Death & Disease (2020)

Article

A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1

Although artemisinin combination therapies have succeeded in reducing the global burden of malaria, multidrug resistance of the deadliest malaria parasite, Plasmodium falciparum, is emerging worldwide. Innovative...

Zhenghui Huang, Ruoxi Li, Tongke Tang, Dazheng Ling, Manjiong Wang… in Cell Discovery (2020)

Article

A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ameliorates hydrogen peroxide-induced oxidative injury and apoptosis in osteoblasts

An ultra-large structure-based virtual screening has discovered iKeap1 as a direct Keap1 inhibitor that can efficiently activate Nrf2 signaling. We here tested its potential effect against hydrogen peroxide (H₂O₂

Yue-huan Zheng, Jian-jun Yang, Pei-jun Tang, Yuan Zhu, Zhe Chen… in Cell Death & Disease (2021)

Article

Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study

Non-clear renal cell carcinomas (nccRCCs) are less frequent in kidney cancer with histopathological heterogeneity. A better understanding of the tumor biology of nccRCC can provide more effective treatment par...

Wen-** Chen, Hao Cao, Jian-wei Cao, Li Zuo, Fa-jun Qu, Da Xu… in Cell Death & Disease (2022)

Article

SAPCD2 promotes neuroblastoma progression by altering the subcellular distribution of E2F7

Recent studies uncovered the emerging roles of SAPCD2 (suppressor anaphase-promoting complex domain containing 2) in several types of human cancer. However, the functions and underlying mechanisms of SAPCD2 in...

Zi-Mu Zhang, Hai-Bo Cao, Zhi-Heng Li, Ran Zhuo, Yan-Fang Tao… in Cell Death & Disease (2022)

Article

A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration

Articular cartilage repair and regeneration is an unmet clinical need because of the poor self-regeneration capacity of the tissue. In this study, we found that the expression of prostaglandin E receptor 4 (PT...

Yunyun **, Qianqian Liu, Peng Chen, Siyuan Zhao, Wenhao Jiang… in Cell Discovery (2022)

Article

m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer

LHPP, a histidine phosphatase, has been implicated in tumour progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive. Here, we obtained GC ti...

Jian-**an Lin, Ning-Zi Lian, You-**n Gao, Qiao-Ling Zheng… in Cell Death & Disease (2022)

Article

RBCK1 regulates the progression of ER-positive breast cancer through the HIF1α signaling

Breast cancer is the most common malignancy in women on a global scale. It can generally be divided into four main categories, of which estrogen receptor ER-positive breast cancer accounts for most breast canc...

Zhiguo Niu, Jianing Fan, Fengzhe Chen, Huijie Yang, **n Li… in Cell Death & Disease (2022)

Article

LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1

One of the characteristics of leukemia is that it contains multiple rearrangements of signal transduction genes and overexpression of non-mutant genes, such as transcription factors. As an important regulator ...

Lihui Lu, Jianwei Wang, Fang Fang, Ailian Guo, Shuting Jiang… in Cell Death & Disease (2023)

Article

Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury

The current study explores the potential function and the underlying mechanisms of endothelial cell-derived R-spondin 3 (RSPO3) neuroprotection against ischemia/reperfusion-induced neuronal cell injury. In bot...

Ting-tao Liu, **n Shi, Hong-wei Hu, Ju-** Chen, Qin Jiang… in Cell Death & Disease (2023)

Article

A genetically encoded ratiometric indicator for tryptophan

Rongkun Tao, Kui Wang, Tian-lun Chen, **n-xin Zhang, Jian-bin Cao… in Cell Discovery (2023)

Article

RBMS3-induced circHECTD1 encoded a novel protein to suppress the vasculogenic mimicry formation in glioblastoma multiforme

Glioblastoma multiforme (GBM) is a highly vascularized malignant cancer of the central nervous system, and the presence of vasculogenic mimicry (VM) severely limits the effectiveness of anti-vascular therapy. ...

Xuelei Ruan, Yunhui Liu, ** Wang, Libo Liu, Teng Ma, Yixue Xue… in Cell Death & Disease (2023)

Article

CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma

Abnormal expression of Cylindromatosis (CYLD), a tumor suppressor molecule, plays an important role in tumor development and treatment. In this work, we found that CYLD binds to class I histone deacetylases (H...

Yueshuo Li, Chenxing Yang, Longlong **e, Feng Shi, Min Tang… in Cell Death & Disease (2024)