32 Result(s)

Article

Increased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway

Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2’s role and the specific mechanism...

Mi Lin, Ru-Hong Tu, Sheng-Ze Wu, Qing Zhong, Kai Weng, Yu-Kai Wu… in Cell Death & Disease (2024)

Article

LncRNA LUESCC promotes esophageal squamous cell carcinoma by targeting the miR-6785-5p/NRSN2 axis

Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent gastrointestinal malignancies with high mortality worldwide. Emerging evidence indicates that long noncoding RNAs (lncRNAs) are involved i...

Song-tao Xue, Shi-qiang Cao, Jian-cheng Ding… in Cellular and Molecular Life Sciences (2024)

Article

PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells

Maintaining genomic stability is a prerequisite for proliferating NPCs to ensure genetic fidelity. Though histone arginine methylation has been shown to play important roles in safeguarding genomic stability, ...

Ya-Jun Wang, Jian-Bo Cao, **g Yang, Tong Liu… in Cellular and Molecular Life Sciences (2024)

Article

Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review

RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they can assembly into ribonucleic acid–protein complexes, which mediate transportation, editi...

Wan‑Jia Qin, **-** Shi, Ru-Yi Chen, Chang-Yun Li… in Cellular & Molecular Biology Letters (2024)

Article

CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma

The oncogenic role of circRNA in cancers including esophageal cancer (EC) has been well studied. However, whether and how circRNAs are involved in cancer cell metabolic processes remains largely unknown. Here,...

Shi-qiang Cao, Song-tao Xue, Wen-juan Li, Guo-sheng Hu, Zhi-gang Wu… in Cell Death Discovery (2024)

Article

CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma

Abnormal expression of Cylindromatosis (CYLD), a tumor suppressor molecule, plays an important role in tumor development and treatment. In this work, we found that CYLD binds to class I histone deacetylases (H...

Yueshuo Li, Chenxing Yang, Longlong **e, Feng Shi, Min Tang… in Cell Death & Disease (2024)

Article

Retraction Note to: Mesothelial cells differentiate into fibroblast-like cells under the scirrhous gastric cancer microenvironment and promote peritoneal carcinomatosis in vitro and in vivo

Zhi-Dong Lv, Hai-Bo Wang, Qian Dong, Bin Kong… in Molecular and Cellular Biochemistry (2024)

Article

RBMS3-induced circHECTD1 encoded a novel protein to suppress the vasculogenic mimicry formation in glioblastoma multiforme

Glioblastoma multiforme (GBM) is a highly vascularized malignant cancer of the central nervous system, and the presence of vasculogenic mimicry (VM) severely limits the effectiveness of anti-vascular therapy. ...

Xuelei Ruan, Yunhui Liu, ** Wang, Libo Liu, Teng Ma, Yixue Xue… in Cell Death & Disease (2023)

Article

Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury

The current study explores the potential function and the underlying mechanisms of endothelial cell-derived R-spondin 3 (RSPO3) neuroprotection against ischemia/reperfusion-induced neuronal cell injury. In bot...

Ting-tao Liu, **n Shi, Hong-wei Hu, Ju-** Chen, Qin Jiang… in Cell Death & Disease (2023)

Article

LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1

One of the characteristics of leukemia is that it contains multiple rearrangements of signal transduction genes and overexpression of non-mutant genes, such as transcription factors. As an important regulator ...

Lihui Lu, Jianwei Wang, Fang Fang, Ailian Guo, Shuting Jiang… in Cell Death & Disease (2023)

Article

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Anillin (ANLN) is a mitosis-related protein that promotes contractile ring formation and cytokinesis, but its cell cycle-dependent degradation mechanisms in cancer cells remain unclear. Here, we show that high...

Yu-Fei Cao, Lei **e, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi… in Cell Death & Differentiation (2023)

Article

Non-invasive plasma testing for CD274 UTR structural variations by next-generation sequencing in cancer

Immunotherapy is now the main choice of systemic therapy for many cancer patients, while current biomarkers for tumor immunotherapy may be limited by the accessibility of patient tumor tissue or tumor neoplast...

Wenjuan Zhang, Jian Cao, Ke Liu, Ziwei Qu, Ying Zheng, Jun Yu… in Cell Death Discovery (2023)

Article

RBCK1 regulates the progression of ER-positive breast cancer through the HIF1α signaling

Breast cancer is the most common malignancy in women on a global scale. It can generally be divided into four main categories, of which estrogen receptor ER-positive breast cancer accounts for most breast canc...

Zhiguo Niu, Jianing Fan, Fengzhe Chen, Huijie Yang, **n Li… in Cell Death & Disease (2022)

Article

Targeting papain-like protease for broad-spectrum coronavirus inhibition

The emergence of SARS-CoV-2 variants of concern and repeated outbreaks of coronavirus epidemics in the past two decades emphasize the need for next-generation pan-coronaviral therapeutics. Drugging the multi-f...

Shuofeng Yuan, **aopan Gao, Kaiming Tang, Jian-Piao Cai, Menglong Hu… in Protein & Cell (2022)

Article

m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer

LHPP, a histidine phosphatase, has been implicated in tumour progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive. Here, we obtained GC ti...

Jian-**an Lin, Ning-Zi Lian, You-**n Gao, Qiao-Ling Zheng… in Cell Death & Disease (2022)

Article

SAPCD2 promotes neuroblastoma progression by altering the subcellular distribution of E2F7

Recent studies uncovered the emerging roles of SAPCD2 (suppressor anaphase-promoting complex domain containing 2) in several types of human cancer. However, the functions and underlying mechanisms of SAPCD2 in...

Zi-Mu Zhang, Hai-Bo Cao, Zhi-Heng Li, Ran Zhuo, Yan-Fang Tao… in Cell Death & Disease (2022)

Article

Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study

Non-clear renal cell carcinomas (nccRCCs) are less frequent in kidney cancer with histopathological heterogeneity. A better understanding of the tumor biology of nccRCC can provide more effective treatment par...

Wen-** Chen, Hao Cao, Jian-wei Cao, Li Zuo, Fa-jun Qu, Da Xu… in Cell Death & Disease (2022)

Article

Correction to: Physalin A induces G2/M phase cell cycle arrest in human non-small cell lung cancer cells: involvement of the p38 MAPK/ROS pathway

Ning Kang, Jun-feng Jian, Shi-jie Cao, Qiang Zhang… in Molecular and Cellular Biochemistry (2022)

Article

Exosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4

Hepatocellular carcinoma (HCC) is a heterogeneous tumor with an increased incidence worldwide accompanied by high mortality and dismal prognosis. Emerging evidence indicates that mesenchymal stem cells (MSCs)-...

Yu-Shui Ma, Ji-Bin Liu, Lan Lin, Hui Zhang, Jian-Jun Wu, Yi Shi… in Cell Death Discovery (2021)

Article

A novel Keap1 inhibitor iKeap1 activates Nrf2 signaling and ameliorates hydrogen peroxide-induced oxidative injury and apoptosis in osteoblasts

An ultra-large structure-based virtual screening has discovered iKeap1 as a direct Keap1 inhibitor that can efficiently activate Nrf2 signaling. We here tested its potential effect against hydrogen peroxide (H₂O₂

Yue-huan Zheng, Jian-jun Yang, Pei-jun Tang, Yuan Zhu, Zhe Chen… in Cell Death & Disease (2021)