6 Result(s)
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Article
Open AccessGenomic analysis of diet composition finds novel loci and associations with health and lifestyle
We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique...
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Article
Open AccessMeta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with...
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Article
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium
Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have id...
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Article
Open AccessPhenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9.
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Article
Open AccessA multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data
Obesity has become an epidemic in many countries and is one of the major risk conditions for disease including type 2 diabetes, coronary heart disease, stroke, dyslipidemia, and hypertension. Recent genome-wid...
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Article
Open AccessMining gene networks with application to GAW15 Problem 1
The Genetic Analysis Workshop 15 (GAW15) Problem 1 contained baseline expression levels of 8793 genes in immortalized B cells from 194 individuals in 14 Centre d'Etude du Polymorphisme Humain (CEPH) Utah pedig...
