3 Result(s)
within
Jiahao He
Biochemistry, general
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Article
Open AccessMechanical stiffness promotes skin fibrosis via Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop
Skin fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) caused by fibrotic disorders of the skin. In recent years, ECM stiffness has emerged as a prominent mechanical cue tha...
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Article
Open AccessMechanical stiffness promotes skin fibrosis through Piezo1-mediated arginine and proline metabolism
The increased mechanics of fibrotic skin tissue continuously regulate fibroblast functions such as survival and differentiation. Although all these processes consume metabolites, it is unclear whether and how ...
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Article
Open AccessMechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1
Hypertrophic scar (HS) formation is a skin fibroproliferative disease that occurs following a cutaneous injury, leading to functional and cosmetic impairment. To date, few therapeutic treatments exhibit satisf...
