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  1. Article

    Open Access

    Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1

    Hypertrophic scar (HS) formation is a skin fibroproliferative disease that occurs following a cutaneous injury, leading to functional and cosmetic impairment. To date, few therapeutic treatments exhibit satisf...

    Jiahao He, Bin Fang, Shengzhou Shan, Yun **e, Chuandong Wang… in Cell Death & Disease (2021)

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  2. Article

    Open Access

    Mechanical stiffness promotes skin fibrosis via Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop

    Skin fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) caused by fibrotic disorders of the skin. In recent years, ECM stiffness has emerged as a prominent mechanical cue tha...

    Jiahao He, **nwei Cheng, Bin Fang, Shengzhou Shan, Qingfeng Li in Cell Death & Disease (2024)

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