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  1. No Access

    Article

    Accelerating the design of pili-enabled living materials using an integrative technological workflow

    Bacteria can be programmed to create engineered living materials (ELMs) with self-healing and evolvable functionalities. However, further development of ELMs is greatly hampered by the lack of engineerable non...

    Yuanyuan Huang, Yanfei Wu, Han Hu, Bangzhuo Tong, Jie Wang… in Nature Chemical Biology (2024)

  2. No Access

    Article

    Tandem intermolecular [4 + 2] cycloadditions are catalysed by glycosylated enzymes for natural product biosynthesis

    Tandem Diels–Alder reactions are frequently used in the construction of polycyclic ring systems in complex organic compounds. Unlike the many Diels−Alderases (DAases) that catalyse a single cycloaddition, enzy...

    Jiawang Liu, Jiayan Lu, Chen Zhang, Qingyang Zhou, Cooper S. Jamieson… in Nature Chemistry (2023)

  3. No Access

    Article

    Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI

    LepI is an S-adenosylmethionine (SAM)-dependent pericyclase that catalyses the formation of the 2-pyridone natural product leporin C. Biochemical characterization has shown that LepI can catalyse stereoselective ...

    Yujuan Cai, Yang Hai, Masao Ohashi, Cooper S. Jamieson… in Nature Chemistry (2019)

  4. No Access

    Article

    Structural basis of nonribosomal peptide macrocyclization in fungi

    Unlike their bacterial counterparts, fungal nonribosomal peptide synthetases utilize a terminal condensation-like (CT) domain to form macrocycles, details of which are illuminated by structures of a CT domain and...

    **ru Zhang, Nicholas Liu, Ralph A Cacho, Zhou Gong, Zhu Liu… in Nature Chemical Biology (2016)

  5. Article

    Open Access

    An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis

    Polyoxin is a group of structurally-related peptidyl nucleoside antibiotics bearing C-5 modifications on the nucleoside skeleton. Although the structural diversity and bioactivity preference of polyoxin are, t...

    Wenqing Chen, Yan Li, Jie Li, Lian Wu, Yan Li, Renxiao Wang, Zixin Deng… in Protein & Cell (2016)

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  6. No Access

    Article

    Solution structure of the Magnaporthe oryzae avirulence protein AvrPiz-t

    Zhi-Min Zhang, Xu Zhang, Zi-Ren Zhou, Hong-Yu Hu, Maili Liu… in Journal of Biomolecular NMR (2013)

  7. No Access

    Article

    Structural determinants of SecB recognition by SecA in bacterial protein translocation

    SecB is a bacterial chaperone involved in directing pre-protein to the translocation pathway by its specific interaction with the peripheral membrane ATPase SecA. The SecB-binding site on SecA is located at it...

    Jiahai Zhou, Zhaohui Xu in Nature Structural & Molecular Biology (2003)