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    Article

    Preso1 dynamically regulates group I metabotropic glutamate receptors

    The authors show that Preso1 acts as a scaffolding protein that binds mGluR, Homer and proline-directed kinases. Deletion of Preso1 prevents phosphorylation of mGluR at the Homer binding site and leads to an i...

    Jia-Hua Hu, Linlin Yang, Paul J Kammermeier, Chester G Moore… in Nature Neuroscience (2012)

  2. No Access

    Article

    Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

    This study shows that the interaction between metabotropic glutamate receptor 5 (mGluR5) and a specific form of the scaffolding protein Homer contributes to the behavioral and physiological defects in the mous...

    Jennifer A Ronesi, Katie A Collins, Seth A Hays, Nien-Pei Tsai… in Nature Neuroscience (2012)