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Open AccessSTX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-κB pathway
Metastatic progression is the main contributor to the poor prognosis of colorectal cancer (CRC). Thus, identifying the determinants of CRC metastasis will be of great significance. Based on our previous bioinf...
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Article
Open AccessMiR-15b and miR-322 inhibit SETD3 expression to repress muscle cell differentiation
SETD3 is a member of SET-domain containing methyltransferase family, which plays critical roles in various biological events. It has been shown that SETD3 could regulate the transcription of myogenic regulator...
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Article
Open AccessIntrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response
Adriamycin(ADR) is still considered to be one of the most effective agents in the treatment of breast cancer (BrCa), its efficacy is compromised by intrinsic resistance or acquire characteristics of multidrug ...
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Article
Open AccessMetadherin enhances vulnerability of cancer cells to ferroptosis
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death driven by lipid hydroperoxides within biological membranes. Although therapy-resistant mesenchymal-high cancers are particularly vul...
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Article
Open AccessBlocking autophagy overcomes resistance to dual histone deacetylase and proteasome inhibition in gynecologic cancer
Histone deacetylase (HDAC) inhibitors and proteasome inhibitors have been approved by the FDA for the treatment of multiple myeloma and lymphoma, respectively, but have not achieved similar activity as single ...
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Open AccessCorrection: Intrinsic adriamycin resistance in p53-mutated breast cancer is related to the miR-30c/FANCF/REV1-mediated DNA damage response
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NK cell dysfunction in patients with COVID-19
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Article
Open AccessHSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice
Heat shock proteins (HSPs) depletion and protein misfolding are important causes of hepatocyte death and liver regeneration disorder in liver injury. HSF2BP, as its name implies, is a binding protein of HSF2, ...