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Article
Open AccessA novel murine model of combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma
Primary liver cancer (PLC) is a common gastrointestinal malignancy worldwide. While hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are two major pathologic types of PLC, combined HCC ...
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Article
Open AccessTumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages
Tumor-associated macrophages (TAM) are immunosuppressive cells that contribute to impaired anti-cancer immunity. Iron plays a critical role in regulating macrophage function. However, it is still elusive wheth...
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Article
Open AccessRNA binding protein Nova1 promotes tumor growth in vivo and its potential mechanism as an oncogene may due to its interaction with GABAA Receptor-γ2
The mechanism of Nova1’s role in hepatocellular carcinoma has not been delineated. Also its interaction with GABAA receptor γ2 in HCC is unveiled. This study is aimed to make it clear the distribution, prognostic...