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  1. No Access

    Article

    A drug discovery platform to identify compounds that inhibit EGFR triple mutants

    Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease. Historically, therapeutics targeting RTKs have been identified using in vitro kinase assays...

    Punit Saraon, Jamie Snider, Yannis Kalaidzidis… in Nature Chemical Biology (2020)

  2. Article

    Upregulation of LYAR induces neuroblastoma cell proliferation and survival

    The N-Myc oncoprotein induces neuroblastoma by regulating gene transcription and consequently causing cell proliferation. Paradoxically, N-Myc is well known to induce apoptosis by upregulating pro-apoptosis ge...

    Yuting Sun, Bernard Atmadibrata, Denise Yu, Matthew Wong… in Cell Death & Differentiation (2017)

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    Article

    Transdermal Delivery of Insulin Using Microneedles in Vivo

    Purpose. The purpose of this study was to design and fabricate arrays of solid microneedles and insert them into the skin of diabetic hairless rats for transdermal delivery of insulin to lower blood glucose leve...

    Wijaya Martanto, Shawn P. Davis, Nicholas R. Holiday, Jenny Wang… in Pharmaceutical Research (2004)

  4. No Access

    Article

    A computationally efficient approach for the design of population pharmacokinetic studies

    A computationally efficient procedure was devised for designing experiments in which population pharmacokinetic parameters are estimated. The method, referred to as the large-sample approach, evaluates the var.....

    Jenny Wang, Laszlo Endrenyi in Journal of Pharmacokinetics and Biopharmaceutics (1992)