6 Result(s)
within
Jennifer L. Gerton
English
Animal Genetics and Genomics
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Article
Ribosomal DNA-connecting ribosome biogenesis and chromosome biology
Ribosomal DNA, the topic of this special issue, has long fascinated biologists. The RNA products of the ribosomal DNA are the ribosomal RNAs that are part of the ribosome. In this special issue, we focus on th...
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Article
Ribosomal DNA and the nucleolus in the context of genome organization
The nucleolus constitutes a prominent nuclear compartment, a membraneless organelle that was first documented in the 1830s. The fact that specific chromosomal regions were present in the nucleolus was recogniz...
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Article
Ribosomal DNA instability and genome adaptability
Ribosomes are large, multi-subunit ribonucleoprotein complexes, essential for protein synthesis. To meet the high cellular demand for ribosomes, all eukaryotes have numerous copies of ribosomal DNA (rDNA) gene...
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Article
Open AccessImproved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome
Roberts syndrome (RBS) is a human developmental disorder caused by mutations in the cohesin acetyltransferase ESCO2. We previously reported that mTORC1 signaling was depressed and overall translation was reduc...
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Article
Open AccessIntersection of ChIP and FLIP, genomic methods to study the dynamics of the cohesin proteins
The evolutionarily conserved cohesin proteins Smc1, Smc3, Rad21 (Mcd1), and Scc3 function in the cohesin complex that provides the basis for chromosome cohesion and is involved in gene regulation. Understandin...
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Article
Homologous chromosome interactions in meiosis: diversity amidst conservation
One of the unique aspects of meiosis is the pairing and exchange of information between homologous chromosomes.
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