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Article
Genome-wide characterization of the routes to pluripotency
Somatic cell reprogramming to a pluripotent state continues to challenge many of our assumptions about cellular specification, and despite major efforts, we lack a complete molecular characterization of the re...
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Article
Divergent reprogramming routes lead to alternative stem-cell states
Pluripotency is defined by the ability of a cell to differentiate to the derivatives of all the three embryonic germ layers: ectoderm, mesoderm and endoderm. Pluripotent cells can be captured via the archetypa...
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Article
Small RNA changes en route to distinct cellular states of induced pluripotency
MicroRNAs (miRNAs) are critical to somatic cell reprogramming into induced pluripotent stem cells (iPSCs), however, exactly how miRNA expression changes support the transition to pluripotency requires further ...
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Article
Open AccessAn epigenomic roadmap to induced pluripotency reveals DNA methylation as a reprogramming modulator
Reprogramming of somatic cells to induced pluripotent stem cells involves a dynamic rearrangement of the epigenetic landscape. To characterize this epigenomic roadmap, we have performed MethylC-seq, ChIP-seq (...
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Article
Correction: Corrigendum: Genome-wide characterization of the routes to pluripotency
Nature 516, 198–206 (2014); doi:10.1038/nature14046 In this Article, the address listed as Nicole Cloonan’s present address (QIMR Berghofer Medical Research Institute, Queensland 4006, Australia) should have b...
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Article
Correction: Corrigendum: Divergent reprogramming routes lead to alternative stem-cell states
Nature 516, 192–197 (2014); doi:10.1038/nature14047 In this Article, the address listed as Nicole Cloonan’s present address (QIMR Berghofer Medical Research Institute, Queensland 4006, Australia) should have b...