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Open AccessHighly efficient transduction of human plasmacytoid dendritic cells without phenotypic and functional maturation
Gene modified dendritic cells (DC) are able to modulate DC functions and induce therapeutic immunity or tolerance in an antigen-specific manner. Among the different DC subsets, plasmacytoid DC (pDC) are well k...
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Article
Open AccessIRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
T cell receptor (TCR) activation is modulated by mechanisms such as TCR endocytosis, which is thought to terminate TCR signalling. Here we show that, upon internalization, TCR continues to signal from a set of...