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  1. Article

    Open Access

    IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

    T cell receptor (TCR) activation is modulated by mechanisms such as TCR endocytosis, which is thought to terminate TCR signalling. Here we show that, upon internalization, TCR continues to signal from a set of...

    Irini Evnouchidou, Pascal Chappert, Samira Benadda… in Nature Communications (2020)

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    Article

    ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

    Induction of cytotoxic T-cell immunity requires the phagocytosis of pathogens, virus-infected or dead tumour cells by dendritic cells1. Peptides derived from phagocytosed antigens are then presented to CD8+ T lym...

    Pierre Guermonprez, Loredana Saveanu, Monique Kleijmeer, Jean Davoust… in Nature (2003)

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    Article

    Differentiation state-dependent surface mobilities of two forms of the neural cell adhesion molecule

    The neural cell adhesion molecule (N-CAM) has been implicated in morphogenetic events during formation of the nervous system1,2. Three forms of N-CAM exist, all glycoprotein chains, of relative molecular masses 1...

    G. Elisabeth Pollerberg, Melitta Schachner, Jean Davoust in Nature (1986)