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Chapter
A Newly Identified Antigen Retention Compartment in the FSDC Precursor Dendritic Cell Line
Antigen uptake and presentation by dendritic cells (DC) occur at different stages of their maturation and are directed by certain cytokines (1–3). Phagocytosis (4) as well as mannose receptor-mediated endocyto...
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Chapter
Dendritic Cells from Mice Lacking the Invariant Chain Express High Levels of Membrane MHC Class II Molecules in Vivo
We investigated in H-2k mice bearing a genetically disrupted invariant chain (Ii) gene1, the MHC class II expression and antigen presentation ability of dendritic cells (DC) freshly purified from the spleen (SpDC...
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Chapter
Checkpoints and Functional Stages in DC Maturation
A major breakthrough in our understanding of the regulation of immune responses has been the discovery of a number of integrated functions of the dendritic cells (DC) in the immune system. To better define the...
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Chapter
Differential mRNA Expression in Untreated and TNF-α Elicited Murine Dendritic Cells Precursors
We have compared the pattern of gene expression in long term cultured precursor dendritic cells (DC), either untreated (immature) or cultured for two days in the presence of recombinant murine (rm)-TNFα1 (mature)...