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  1. Article

    Open Access

    Peripheral natural killer cells and myeloid-derived suppressor cells correlate with anti-PD-1 responses in non-small cell lung cancer

    Inhibition of immune checkpoint proteins like programmed death 1 (PD-1) is a promising therapeutic approach for several cancers, including non-small cell lung cancer (NSCLC). Although PD-1 ligand (PD-L1) expre...

    Je-In Youn, Su-Myeong Park, Seyeon Park, Gamin Kim, Hee-Jae Lee… in Scientific Reports (2020)

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  2. No Access

    Article

    Role of myeloid-derived suppressor cells in immune checkpoint inhibitor therapy in cancer

    Over the past decade, immune checkpoint inhibitor (ICI) therapy has demonstrated improved therapeutic efficacy in a wide range of cancers. However, the benefits are restricted to a small population of patients...

    Su-Myeong Park, Je-In Youn in Archives of Pharmacal Research (2019)

  3. Article

    Open Access

    Loss of Rb1 by epigenetic modification regulates expansion of MDSC in cancer

    Je-In Youn, Kyungwha Lee, Hai-Chon Lee… in Journal for ImmunoTherapy of Cancer (2014)

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  4. Article

    Open Access

    Transcriptional regulation of IFN-λ genes in Hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-κB complex

    Hai-Chon Lee, Je-In Youn, Kyungwha Lee, Hwanyul Yong… in Journal for ImmunoTherapy of Cancer (2014)

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  5. No Access

    Article

    Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer

    Gabrilovich and colleagues show that monocytic myeloid-derived suppressor cells (MDSCs) differentiate into polymorphonuclear MDSCs in individuals with tumors, demonstrating a demonstrating a distinct regulatio...

    Je-In Youn, Vinit Kumar, Michelle Collazo, Yulia Nefedova… in Nature Immunology (2013)