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Article
Dominant-negative CREB inhibits tumor growth and metastasis of human melanoma cells
The ATF/CREB family of eukaryotic transcription factors contain the bZIP structural motif and mediate their transcriptional activities via heterodimerization with ATF and AP-1 family members. Quenching of CREB...
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Article
Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol
We recently found that overexpression of p185c-erbB2 in c-erbB2 transfected MDA-MB-435 breast cancer cells (435.eB transfectants) confers a 5–9-fold increase in Taxol resistance. To examine whether Taxol resistan...