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Article
Open AccessCoronary artery reperfusion: The ADP receptor P2Y1 mediates early reactive hyperemia in vivo in pigs
The physiological mechanisms that regulate reactive hyperemia are not fully understood. We postulated that the endothelial P2Y1 receptor that release vasodilatory factors in response to ADP might play a vital rol...
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Article
Open AccessMild hypothermia reduces cardiac post-ischemic reactive hyperemia
In experimentally induced myocardial infarction, mild hypothermia (33–35°C) is beneficial if applied prior to ischemia or reperfusion. Hypothermia, when applied after reperfusion seems to confer little or no b...
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Article
Open AccessIntimal Hyperplasia in Balloon Dilated Coronary Arteries is Reduced by Local Delivery of the NO Donor, SIN-1 Via a cGMP-Dependent Pathway
To elucidate the mechanism by which local delivery of 3-morpholino-sydnonimine (SIN-1) affects intimal hyperplasia after percutaneous transluminal coronary angioplasty (PTCA).
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Article
Open AccessEvaluation of coronary blood flow velocity during cardiac arrest with circulation maintained through mechanical chest compressions in a porcine model
Mechanical chest compressions (CCs) have been shown capable of maintaining circulation in humans suffering cardiac arrest for extensive periods of time. Reports have documented a visually normalized coronary b...
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Article
Open AccessA pharmacodynamic comparison of 5 anti-platelet protocols in patients with ST-elevation myocardial infarction undergoing primary PCI
Despite advances in anti-platelet treatments, there still exists an early increase in both ischemic as well as bleeding events following primary PCI in patients with ST-elevation myocardial infarction (STEMI)....
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Article
Open AccessMechanical chest compressions in the coronary catheterization laboratory to facilitate coronary intervention and survival in patients requiring prolonged resuscitation efforts
Resuscitation after cardiac arrest (CA) in the catheterization laboratory (cath-lab) using mechanical chest compressions (CC) during simultaneous percutaneous coronary intervention (PCI) is a strong recommenda...
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Article
Open AccessThe safety of introducing a new generation TAVR device: one departments experience from introducing a second generation repositionable TAVR
In the evolving field of transcatheter aortic valve replacements a new generation of valves have been introduced to clinical practice. With the complexity of the TAVR procedure and the unique aspects of each T...
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Article
Open AccessAssessment of increasing intravenous adenosine dose in fractional flow reserve
Effects of increased adenosine dose in the assessment of fractional flow reserve (FFR) were studied in relation to FFR results, hemodynamic effects and patient discomfort. FFR require maximal hyperemia mediate...
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Article
Open AccessSingle-center evaluation of a next generation fully repositionable and retrievable transcatheter aortic valve replacement
The mechanically expandable Lotus Valve System is a fully repositionable and retrievable valve with an adaptive seal to minimize paravalvular leak (PVL). The aim of this study was to evaluate the short- and lo...
