30 Result(s)
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Article
Achieving equity through science and integrity: dismantling race-based medicine
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Article
“Racism as a public health issue” APS racism series: at the intersection of equity, science, and social justice
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Open AccessThe feasibility of develo** biomarkers from peripheral blood mononuclear cell RNAseq data in children with juvenile idiopathic arthritis using machine learning approaches
The response to treatment for juvenile idiopathic arthritis (JIA) can be staged using clinical features. However, objective laboratory biomarkers of remission are still lacking. In this study, we used machine ...
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Open AccessPlasma exosomes from children with juvenile dermatomyositis are taken up by human aortic endothelial cells and are associated with altered gene expression in those cells
The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and under-investigated. We have hyp...
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Open AccessChromatin landscapes and genetic risk for juvenile idiopathic arthritis
The transcriptomes of peripheral blood cells in children with juvenile idiopathic arthritis (JIA) have distinct transcriptional aberrations that suggest impairment of transcriptional regulation. To gain a bett...
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Open AccessChromatin landscapes and genetic risk in systemic lupus
Systemic lupus erythematosus (SLE) is a multi-system, complex disease in which the environment interacts with inherited genes to produce broad phenotypes with inter-individual variability. Of 46 single nucleot...
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Open AccessProceedings of the 2016 Childhood Arthritis and Rheumatology Research Alliance (CARRA) Scientific Meeting
P1 Serologic evidence of gut-driven systemic inflammation in juvenile idiopathic arthritis
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Open AccessWhole blood expression profiling from the TREAT trial: insights for the pathogenesis of polyarticular juvenile idiopathic arthritis
The Trial of Early Aggressive Therapy in Juvenile Idiopathic Arthritis (TREAT trial) was accompanied by a once-in-a-generation sample collection for translational research. In this paper, we report the results...
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Caregiver Demand and Parent Distress in Juvenile Rheumatic Disease: The Mediating Effect of Parent Attitude Toward Illness
Parents of youth with juvenile rheumatic diseases (JRD) often take on illness management responsibilities that can become burdensome, potentially resulting in poor parent adjustment outcomes. However, not all ...
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Open AccessGenomic characterization of remission in juvenile idiopathic arthritis
The attainment of remission has become an important end point for clinical trials in juvenile idiopathic arthritis (JIA), although we do not yet have a full understanding of what remission is at the cell and m...
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Open AccessCommentary – ordering lab tests for suspected rheumatic disease
One of the least-appreciated advances in pediatric rheumatology over the past 25 years has been the delineation of the many ways in which children with rheumatic disease differ from adults with the same illnes...
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Open AccessNeutrophils: the forgotten cell in JIA disease pathogenesis
Juvenile idiopathic arthritis (JIA) has long been assumed to be an autoimmune disease, triggered by aberrant recognition of "self" antigens by T-cells. However, systems biology approaches to this family of dis...
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Open AccessEvidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis
Although strong epidemiologic evidence suggests an important role for adaptive immunity in the pathogenesis of polyarticular juvenile rheumatoid arthritis (JRA), there remain many aspects of the disease that s...
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Open AccessChronic arthritis in children and adolescents in two Indian health service user populations
High prevalence rates for rheumatoid arthritis, spondyloarthopathies, and systemic lupus erythematosus have been described in American Indian and Alaskan Native adults. The impact of these diseases on American...
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Open AccessClinical utility of antinuclear antibody tests in children
Antinuclear antibody (ANA) tests are frequently used to screen children for chronic inflammatory diseases such as systemic lupus erythematosus (SLE). However, the diagnostic utility of this test is limited bec...
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Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis
Juvenile rheumatoid arthritis (JRA) has a complex, poorly characterized pathophysiology. Modeling of transcriptosome behavior in pathologic specimens using microarrays allows molecular dissection of complex au...
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Phosphorylation of the Complement Receptor, CR1 (CD35), and Its Association with the Syk Tyrosine Kinase in Immune Complex-Stimulated HL-60 Cells
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Activation of Human Umbilical Vein Endothelial Cells by C1q-Bearing Immune Complexes
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Role of Immune Complex Size and Complement Binding in Regulating Monocyte Responses to Immune Complexes • 1982
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Human Choriocarcinoma JAR Cells Constitutively Express Pro-Interleukin-1β That Can Be Released with Fcγ Receptor Engagement
Some authors have suggested that fetally derived syncytiotrophoblasts, which form the barrier between mother and the fetus, are an integral part of a complex macrophage-cytokine network involving maternal leuk...
