5 Result(s)
-
Article
Open AccessInhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy
Immunotherapies targeting the PD-1/PD-L1 axis are now a mainstay in the clinical management of multiple cancer types, however, many tumors still fail to respond. CCL2 is highly expressed in various cancer type...
-
Article
A community effort to assess and improve drug sensitivity prediction algorithms
A community of researchers report the lessons learned from applying 44 algorithms to predict drug sensitivity in cancer cell lines using genomic, epigenetic and proteomic datasets
-
Article
A community computational challenge to predict the activity of pairs of compounds
A community computational challenge generates algorithms to predict activity of drug combinations.
-
Article
Wisdom of crowds for robust gene network inference
This analysis comprehensively compares methods for gene regulatory network inference submitted through the DREAM5 challenge. It demonstrates that integration of predictions from multiple methods shows the most...
-
Chapter and Conference Paper
Limitations of Pseudogenes in Identifying Gene Losses
The loss of previously established genes has been proposed as a major force in evolutionary change. While the sequencing of many new species offers the opportunity to identify cases of gene loss, the best meth...
