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Knowledge Management and Sustainable Development

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  1. Article

    Open Access

    Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition

    Here we demonstrate for the first time that targeted inhibition of nuclear exporter protein exportin 1 (XPO1) also known as chromosome maintenance region 1 (CRM1) by Selective Inhibitor of Nuclear Export (SINE...

    Asfar S. Azmi, Irfana Muqbil, Jack Wu, Amro Aboukameel… in Scientific Reports (2015)

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  2. Article

    Open Access

    An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

    MI-319 is a synthetic small molecule designed to target the MDM2-P53 interaction. It is closely related to MDM2 antagonists MI-219 and Nutlin-3 in terms of the expected working mechanisms. The purpose of this ...

    Ramzi M Mohammad, Jack Wu, Asfar S Azmi, Amro Aboukameel, Angela Sosin… in Molecular Cancer (2009)

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