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An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

MI-319 is a synthetic small molecule designed to target the MDM2-P53 interaction. It is closely related to MDM2 antagonists MI-219 and Nutlin-3 in terms of the expected working mechanisms. The purpose of this ...

Ramzi M Mohammad, Jack Wu, Asfar S Azmi, Amro Aboukameel, Angela Sosin… in Molecular Cancer (2009)