21 Result(s)

Article

Genetic alterations and their clinical implications in older patients with acute myeloid leukemia

A number of patient-specific and leukemia-associated factors are related to the poor outcome in older patients with acute myeloid leukemia (AML). However, comprehensive studies regarding the impact of genetic ...

C-H Tsai, H-A Hou, J-L Tang, C-Y Liu, C-C Lin, W-C Chou, M-H Tseng, Y-C Chiang… in Leukemia (2016)

Article

Integration of cytogenetic and molecular alterations in risk stratification of 318 patients with de novo non-M3 acute myeloid leukemia

Conventionally, acute myeloid leukemia (AML) patients are categorized into good-, intermediate- and poor-risk groups according to cytogenetic changes. However, patients with intermediate-risk cytogenetics repr...

H-A Hou, C-C Lin, W-C Chou, C-Y Liu, C-Y Chen, J-L Tang, Y-J Lai, M-H Tseng… in Leukemia (2014)

Article

The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia

Although the clinical features of the Isocitrate dehydrogenase 2 (IDH2) mutation in acute myeloid leukemia (AML) have been characterized, its prognostic significance remains controversial and its stability has no...

W-C Chou, W-C Lei, B-S Ko, H-A Hou, C-Y Chen, J-L Tang, M Yao, W Tsay, S-J Wu… in Leukemia (2011)

Article

Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients

Acute myeloid leukemia (AML) with t(7;11)(p15;p15), which results in a NUP98–HOXA9 fusion, is a distinct entity, but this subtype has not been characterized in detail. In a comprehensive study comparing 11 such p...

W-C Chou, C-Y Chen, H-A Hou, L-I Lin, J-L Tang, M Yao, W Tsay, B-S Ko, S-J Wu… in Leukemia (2009)

Article

Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase

Dasatinib is an inhibitor of BCR-ABL and SRC-family kinases for patients with imatinib-resistant or -intolerant chronic myelogenous leukemia (CML). In this international phase II trial, dasatinib was administe...

J Cortes, D-W Kim, E Raffoux, G Martinelli, E Ritchie, L Roy, S Coutre, S Corm… in Leukemia (2008)

Article

Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD

H-A Hou, W-C Chou, L-I Lin, C-Y Chen, J-L Tang, M-H Tseng, C-F Huang, R-J Chiou… in Leukemia (2008)

Article

Comparison of hypoplastic myelodysplastic syndrome (MDS) with normo-/hypercellular MDS by International Prognostic Scoring System, cytogenetic and genetic studies

The differences in clinical features and prognosis between hypoplastic myelodysplastic syndrome (h-MDS) and normo-/hypercellular MDS (NH-MDS) remain unsettled. In this study, the characteristics of 37 h-MDS pa...

T-C Huang, B-S Ko, J-L Tang, C Hsu, C-Y Chen, W Tsay, S-Y Huang, M Yao… in Leukemia (2008)

Article

Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) mutations

To explore the validity and prognostic significance of minimal residual disease detection by quantitative polymerase chain reaction (qPCR) in patients of acute myeloid leukemia (AML) bearing Nucleophosmin (NPM1) ...

W-C Chou, J-L Tang, S-J Wu, W Tsay, M Yao, S-Y Huang, K-C Huang, C-Y Chen… in Leukemia (2007)

Article

A novel fluorescence-based multiplex PCR assay for rapid simultaneous detection of CEBPA mutations and NPM mutations in patients with acute myeloid leukemias

L-I Lin, T-C Lin, W-C Chou, J-L Tang, D-T Lin, H-F Tien in Leukemia (2006)

Article

Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome

C-Y Chen, L-I Lin, J-L Tang, W Tsay, H-H Chang, Y-C Yeh, C-F Huang, R-J Chiou… in Leukemia (2006)

Article

Clinical and biological implications of partial tandem duplication of the MLL gene in acute myeloid leukemia without chromosomal abnormalities at 11q23

The clinical and biological features of acute myeloid leukemia (AML) with 11q23/MLL translocations are well known, but the characteristics of AML with partial tandem duplication of the MLL gene have not been e...

H-S Shiah, Y-Y Kuo, J-L Tang, S-Y Huang, M Yao, W Tsay, Y-C Chen, C-H Wang… in Leukemia (2002)

Article

Characterization of acute myeloid leukemia with MLL rearrangements – no increase in the incidence of coexpression of lymphoid-associated antigens on leukemic blasts

MLL gene rearrangements are associated with coexpression of myeloid- and lymphoid-associated antigens on leukemic blasts and a dismal outcome in acute lymphoblastic leukemia (ALL). Whether the same conditions ...

H-F Tien, C-H Hsiao, J-L Tang, W Tsay, C-H Hu, Y-Y Kuo, C-H Wang, Y-C Chen… in Leukemia (2000)

Article

Minimally differentiated acute myeloid leukemia in Taiwan: predominantly occurs in children less than 3 years and adults between 51 and 70 years

Acute myeloid leukemia (AML) with minimal differentiation was usually referred to as acute undifferentiated leukemia in the past. With the help of immunophenoty**, this subtype of leukemia was shown to expre...

S-Y Huang, J-L Tang, S-T Jou, W Tsay, C-H Hu, D-T Lin, K-S Lin, K-S Lin… in Leukemia (1999)

Article

Extramedullary relapse after all-trans retinoic acid treatment in acute promyelocytic leukemia – the occurrence of retinoic acid syndrome is a risk factor

All-trans retinoic acid (ATRA) is now a standard agent for remission induction of acute promyelocytic leukemia (APL). Recently, extramedullary relapse, which was a rare condition in APL patients after chemotherap...

B-S Ko, J-L Tang, Y-C Chen, M Yao, C-H Wang, M-C Shen, H-F Tien in Leukemia (1999)