25 Result(s)

Chapter

Animal Experimentation

Animal experimentation and research with animals is integrated into surgical research at two levels: perplexing problems encountered in clinical practice are taken to the animal laboratory for simplification a...

W. H. Isselhard, J. Kusche in Surgical Research (1998)

Article

Diamine oxidase activities in the large bowel mucosa of ulcerative colitis patients

The term colitis suggests mucosal inflammation as the key event. However, it may be that the disease starts with mucosal hyperproliferation, and inflammation of the impaired mucosa is a succeeding event. There...

Priv. Doz. Dr. med. R. Mennigen, J. Kusche, C. Streffer, B. Krakamp in Agents and Actions (1990)

Article

The histamine-diamine oxidase system and mucosal proliferation under the influence of aminoguanidine and seventy percent resection of the rat small intestine

We have suggested previously that the histamine-diamine oxidase system is involved in cell proliferation. Therefore, the diamine oxidase activity and the histamine content were studied during mucosal prolifera...

R. Mennigen, T. Bieganski, A. Elbers, J. Kusche in Agents and Actions (1989)

Article

Early alterations of rat intestinal diamine oxidase activity by azoxymethane, an intestinal carcinogen

Some mutagenic hydrazino compounds are also diamine oxidase inhibitors. Therefore, this interrelationship was studied for the intestinal carcinogen azoxymethane.In vitro, azoxymethane was a very weak inhibitor of...

J. Kusche, R. Mennigen, L. Leisten in Agents and Actions (1989)

Article

The intestinal diamine oxidase activity under the influence of adaptive proliferation of the intestinal mucosa — a proliferation terminating principle?

Under clinical conditions, intestinal mucosal hyperproliferation together with a reduced diamine oxidase (DAO) activity was found in inflammatory and neoplastic diseases. Therefore, we studied the influence on...

J. Kusche, R. Mennigen, K. Erpenbach in Agents and Actions (1988)

Article

Reliability and practicability of the fluorometric-fluoroenzymatic histamine determination in pathogenetic studies on peptic ulcer: Detection limits and problems with specificity

Histamine, among various “biologic-physiologic” abnormalities, is considered as a pathogenetic factor in chronic duodenal ulcer disease. The 10–30 per cent difference between its concentration in gastric and d...

Prof. Dr. W. Lorenz, K. Thon, E. Neugebauer, H. Stöltzing, Ch. Ohmann… in Agents and Actions (1987)

Article

Elevation of the large bowel histamine concentration by aminoguanidine induced diamine oxidase inhibition

In inflammatory diseases of the large bowel a reduced diamine oxidase activity was found which may be related to a reduced oxidative degradation of histamine. An experimental inhibition of diamine oxidase coul...

J. Kusche, R. Mennigen, L. Leisten, B. Amoei in Agents and Actions (1987)

Article

Prof. Dr. Dankwart ACKERMANN —The 20th anniversary of his death

J. Kusche, J. V. Parkin in Agents and Actions (1986)

Article

Diamine oxidase as a marker of intestinal integrity in acute appendicitis

In the operative treatment of appendicitis the so called negative appendectomy is an important issue because of its increased morbidity. From the hypothesis that the intestinal diamine oxidase activity is a su...

R. Menningen, M. Günther, N. Bönninghoff, C. -D. Stahlknecht… in Agents and Actions (1986)

Article

Histamine reduces the deamination of putrescinein vitro—but alsoin vivo?

The diamine oxidase catalysed deamination of putrescine was reducedin vitro by histamine at concentrations occurring in the gut. An oral application of histamine, however, had no effect on the enzymic activity. W...

J. Kusche, R. Mennigen, I. Rosenthal in Agents and Actions (1985)

Article

N-methyl-N-formylhydrazine: A toxic and mutagenic inhibitor of the intestinal diamine oxidase

N-methyl-N-formylhydrazine is the first active intermediate of the poison gyromitrin of the mushroom: false morel. This compound is a non-competitive inhibitor of human intestinal diamine oxidase (ID₅₀=1.6×10⁻⁵ ...

T. Biegński, R. Braun, J. Kusche in Agents and Actions (1984)

Article

Plasma histamine levels in patients in the course of several standard operations: Influence of anaesthesia, surgical trauma and blood transfusion

A prospective controlled clinical trial was conducted on changes in plasma histamine and catecholamine levels during 5 standard operations. This communication, as the first part of the trial, deals only with t...

Prof. Dr. H. D. Röher, W. Lorenz, H. Lennartz, J. Kusche… in Klinische Wochenschrift (1982)

Article

Intestinal monoamine oxidase: Does it have a role in histamine catabolism?

The importance of intestinal diamine oxidase in histamine catabolism was proved in several series of experiments. However, intestinal monoamine oxidase might also be involved in histamine degradation either by...

J. Kusche, K. -D. Feußner, W. Lorenz in Agents and Actions (1982)

Article

The start of a programme for measuring diamine oxidase activity in biopsy specimens of human rectal mucosa

In human subjects, apart from in the kidney, diamine oxidase occurs mainly in the gut. Therefore this enzyme can be used as an indicator of intestinal integrity.

R. Hesterberg, J. Kusche, C. -D. Stahlknecht, K. -D. Feussner in Agents and Actions (1981)

Article

Human intestinal diamine oxidase: Substrate specificity and comparative inhibitor study

For an 80-fold purified preparation of human intestinal diamine oxidase the optimum conditions of incubation, the substrate and the inhibitor specificity were tested. Putrescine was the most favoured substrate...

T. Biegański, J. Kusche, K. -D. Feußner, R. Hesterberg, H. Richter… in Agents and Actions (1980)

Article

The influence of carcinoma growth on diamine oxidase activity in human gastrointestinal tract

The distribution of diamine oxidase (DAO) activity was studied in patients having no carcinoma disease. Besides in gut DAO occurred in high activity only in kidney and mesenteric lymph nodes.

J. Kusche, T. Biegański, R. Hesterberg, C. -D. Stahlknecht… in Agents and Actions (1980)

Article

Comparison of alterations in the histamine-diamine oxidase system during acute intestinal ischaemia in pigs, dogs and rabbits: Evidence for a uniform pathophysiological mechanism?

J. Kusche, C. D. Stahlknecht, W. Lorenz, G. Reichert, W. Dietz in Agents and Actions (1979)

Article

Diamine oxidase activity in gastric and duodenal mucosa of man and other mammals with special reference to the pyloric junction

In the gastric mucosa of human subjects and of various mammals methylation was accepted as the main pathway of histamine catabolism. However, augmentation of gastric acid secretion by aminoguanidine, the stron...

J. Kusche, W. Lorenz, C. -D. Stahlknecht, A. Friedrich, A. Schmidt… in Agents and Actions (1978)

Article

Diamine oxidase activity and histamine release in dogs following acute mesenteric artery occlusion

Following superior mesenteric artery occlusion and revasclarization in dogs all animals died in a circulatory collapse state. However, pretreatment by aminoguanidine, the strong and specific inhibitor of diami...

J. Kusche, C. -D. Stahlknecht, W. Lorenz, G. Reichert, H. Richter in Agents and Actions (1977)

Article

Determination of histaminase (diamine oxidase) activity byo-dianisidine test: Interference of ceruloplasmin

Until nowo-dianisidine was used as an indicator substance in a test system for the determination of diamine oxidase. More recently, however, this substance was also used to measure ceruloplasmin activity. A study...

T. Biegański, M. Z. Blasinska, J. Kusche in Agents and Actions (1977)