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  1. Article

    IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

    Interferon regulatory factor-1 (IRF-1) is a transcription factor that acts as a tumor suppressor and causes apoptosis in cancer cells. We evaluated IRF-1-induced apoptosis in gastric cancer cell lines. We esta...

    J Gao, M Senthil, B Ren, J Yan, Q **ng, J Yu, L Zhang… in Cell Death & Differentiation (2010)

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  2. Article

    The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death

    Glioma tumor suppressor candidate region gene 2 (GLTSCR2/PICT-1) is localized within the well-known 1.4-Mb tumor suppressive region of chromosome 19q, which is frequently altered in various human tumors, inclu...

    J-H Yim, Y-J Kim, J-H Ko, Y-E Cho, S-M Kim, J-Y Kim, S Lee… in Cell Death & Differentiation (2007)

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    Article

    Interferon regulatory factor-1-induced apoptosis mediated by a ligand-independent fas-associated death domain pathway in breast cancer cells

    Interferon (IFN) regulatory factor-1 (IRF-1) is a transcription factor that has apoptotic anti-tumor activity. In breast cancer cell types, IRF-1 is implicated in mediating apoptosis by both novel and establis...

    M T Stang, M J Armstrong, G A Watson, K Y Sung, Y Liu, B Ren, J H Yim in Oncogene (2007)