11 Result(s)
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Article
NEONATAL SCREENING FOR CONGENITAL ADRENAL HYPERPLASIA (CAH) USING 17-HYDROXYPROGESTERONE (17-OHP) ASSAYS OF DRIED BLOOD SPOTS
Dried blood on filter paper collected on the 5th day of life was used to screen infants for CAH. A radioimmunoassay for 17-OHP without extraction with organic solvents was developed. The cut-off level was init...
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Article
Glucose Production Rate in Extremely Immature Neonates (<28 Weeks) Studied by Use of Deuterated Glucose
ABSTRACT: Neonatal hypoglycemia is a frequent complication in immature infants. This may be due to small substrate stores, a high brain:body weight ratio, and immature enzyme systems. The purpose of the presen...
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Article
GROWTH HORMONE THERAPY OF CHILDREN WITH DOWN SYNDROME RESULTS IN NORMALIZED GROWTH VELOCITY
Growth velocity is markedly reduced in children with Down syndrome (DS) between 6 months and 3 years of age, but is almost normal after 3 years of age. Thus, the growth retardation becomes pronounced during th...
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Article
The adrenal autoantigen in APSI is the side-chain cleavage enzyme
Autoimmune potyendocrine syndrome type I (Blizzard's syndrome) is an autosomal recessively inherited disease associated with multiple endocrine and non-endocrine manifestations such as autoimmune hypoparathvro...
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Article
Very Immature Infants (≤ 30 Wk) Respond to Glucose Infusion with Incomplete Suppression of Glucose Production
ABSTRACT: Small substrate stores and immature enzyme systems make preterm infants prone to develop hypoglycemia. Hy-perglycemia may also occur, particularly when these infants are given i.v. glucose. To evalua...
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Article
Pubertal development and final height after autologous bone marrow transplantation for acute lymphoblastic leukemia
We describe pubertal development and growth in 17 children who underwent bone marrow transplantation (BMT), including total body irradiation (TBI) for ALL. Seven children also received cranial irradiation (CI)...
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73 Metabolic Adaptation in Infants Born Small for Gestational Age
Background: After birth the newborn infant must produce its own glucose until breastfeeding is established. Infants born small for gestational age (SGA) are at risk for neonatal hypoglycemia and development of me...
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3 Increased Lipolysis in Large for Gestational Age Infants
Background: During late gestation the fetus accumulates fat and glycogen for the immediate postnatal period. Newborn infants of diabetic mothers as well as other infants with hyperinsulinemia have particularly la...
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Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon
Mesenchymal stem cells (MSC) possess anti-inflammatory properties and participate in tissue repair. We used MSC to heal therapy-induced tissue toxicity. Ten consecutive patients, treated with MSC due to tissue...
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Article
Glucose metabolism and body composition in young adults treated with TBI during childhood
After SCT in childhood, survivors may develop disorders of glucose metabolism. The role of obesity is controversial. We measured insulin sensitivity using the homeostasis model assessment (HOMA) and the freque...
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Article
Decreased bone mineral density in young adults treated with SCT in childhood: the role of 25-hydroxyvitamin D
We measured bone mineral density (BMD) with dual-energy X-ray absorptiometry in the total body, at the lumbar spine, at the femoral neck and in the total hip, in 18 young adults with a median of 18.2 years aft...
