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  1. No Access

    Article

    Endoscopic drainage with local infusion of antibiotics to avoid necrosectomy of infected walled-off necrosis

    Current treatment of infected pancreatic necrosis (IPN) follows a step-up approach. Our group designed a step-up protocol that associates endoscopic drainage with local infusion of antibiotics through transmur...

    Jose Lariño-Noia, Daniel de la Iglesia-García, Jaime González-Lopez… in Surgical Endoscopy (2021)

  2. Article

    Open Access

    Differences in In Vitro Properties of Pancreatin Preparations for Pancreatic Exocrine Insufficiency as Marketed in Russia and CIS

    Pancreatic enzyme-replacement therapy (PERT), provided as pancreatin to patients with pancreatic exocrine insufficiency (PEI), is considered an essential substitute for the pivotal physiological function the p...

    Igor V. Maev, Yury A. Kucheryavyy, Natalya B. Gubergrits, Ingo Bonnacker… in Drugs in R&D (2020)

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  3. Article

    Open Access

    Exocrine Pancreatic Insufficiency Following Acute Pancreatitis: Systematic Review and Meta-Analysis

    The epidemiology of exocrine pancreatic insufficiency (EPI) after acute pancreatitis (AP) is uncertain. We sought to determine the prevalence, progression, etiology and pancreatic enzyme replacement therapy (P...

    Wei Huang, Daniel de la Iglesia-García, Iria Baston-Rey… in Digestive Diseases and Sciences (2019)

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  4. No Access

    Chapter

    Exocrine Pancreatic Function in Diabetes

    The pancreas should be considered as a single endocrine–exocrine gland with complex insulo-acinar-ductal communications. Insulin exerts a trophic and stimulatory effect on the acinar cells, digestive enzymes s...

    J. Enrique Domínguez-Muñoz, Beatriz Cigarrán in Gastrointestinal Complications of Diabetes (2018)

  5. No Access

    Article

    Chronic pancreatitis

    Chronic pancreatitis is defined as a pathological fibro-inflammatory syndrome of the pancreas in individuals with genetic, environmental and/or other risk factors who develop persistent pathological responses ...

    Jorg Kleeff, David C. Whitcomb, Tooru Shimosegawa… in Nature Reviews Disease Primers (2017)

  6. No Access

    Article

    Potential for Screening for Pancreatic Exocrine Insufficiency Using the Fecal Elastase-1 Test

    The early diagnosis of pancreatic exocrine insufficiency (PEI) is hindered because many of the functional diagnostic techniques used are expensive and require specialized facilities, which prevent their widesp...

    J. Enrique Domínguez-Muñoz, Philip D. Hardt… in Digestive Diseases and Sciences (2017)

  7. No Access

    Chapter

    Natural Course of Chronic Pancreatitis

    J. Enrique Domínguez-Muñoz in Diseases of the Pancreas (2008)

  8. No Access

    Article

    Clinical Response (Remission of Symptoms) in Erosive and Non-Erosive Gastro-Oesophageal Reflux Disease

    Complete remission of symptoms and prevention of symptomatic recurrence are among the main therapeutic aims in gastro-oesophageal reflux disease (GORD). In this context, a potent pharmacologic inhibition of ga...

    J. Enrique Domínguez-Muñoz, Miguel Sobrino in Drugs (2005)

  9. No Access

    Article

    Early antibiotic treatment (prophylaxis) of septic complications in severe acute necrotizing pancreatitis: a prospective, randomized, multicenter study comparing two regimens with imipenem-cilastatin

    We compared two imipenem regimens for prevention of septic complications in patients with severe acute necrotizing pancreatitis (ANP).

    Enrique Maraví-Poma, Joan Gener, Francisco Alvarez-Lerma… in Intensive Care Medicine (2003)

  10. No Access

    Article

    Hyperlipidemia in acute pancreatitis

    Whether hyperlipidemia is a pre-existing metabolic disorder or a consequence of acute pancreatitis is still debated. Mild to moderate elevation of serum triglyceride levels are likely to be an epiphenomenon of...

    J. Enrique Domínguez-Muñoz, Frank Jünemann… in International journal of pancreatology (1995)

  11. No Access

    Article

    Assessment of the fibrogenetic activity in chronic pancreatitis

    Determination of circulating levels of extracellular matrix components has been proposed as a reliable method to assess the activity of fibrogenetic processes. Therefore, we aimed to analyze circulating levels...

    J. Enrique Domínguez-Muñoz, Gianpiero Manes… in International journal of pancreatology (1993)

  12. No Access

    Article

    Prognostic factors in acute pancreatitis

    Peter Malfertheiner, J. Enrique Domínguez-Muñoz in International journal of pancreatology (1993)