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Article

Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy

In most clinical trials, human mesenchymal stem cells (hMSCs) are expanded in vitro before implantation. The genetic stability of human stem cells is critical for their clinical use. However, the relationship bet...

J C Estrada, Y Torres, A Benguría, A Dopazo, E Roche… in Cell Death & Disease (2013)