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The stability of Killing–Cauchy horizons in colliding plane wave space-times
It is confirmed rigorously that the Killing–Cauchy horizons, which sometimes occur in space-times representing the collision and subsequent interaction of plane gravitational waves in a Minkowski background, are
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Null Limits of the C-Metric
The C-metric is usually understood as describing two black holes which accelerate in opposite directions under the action of some conical singularity. Here, we examine all the solutions of this type which repr...
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Null Limits of Generalised Bonnor-Swaminarayan Solutions
The Bonnor-Swaminarayan solutions are boost-rotation symmetric space-times which describe the motion of pairs of accelerating particles which are possibly connected to strings (struts). In an explicit and unif...
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An integrated strategy for the process development of a recombinant antibody-cytokine fusion protein expressed in BHK cells
Recombinant fusion proteins offer important new therapeutic approaches for the future. This report describes the use of three different genetic strategies (i.e. “mono-”, “bi-” and “tri-cistronic” vectors) to ...
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The Extensions of Gravitational Soliton Solutions with Real Poles
We analyse vacuum gravitational“soliton” solutions with real poles in thecosmological context. It is well known that thesesolutions contain singularities on certain nullhypersurfaces. Using a Kasner seed solut...
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Alternative Strategies for the Production of an Antibody-Cytokine Fusion Protein from Recombinant BHK Cells
The choice of scale up strategies for production of recombinant proteins from animal cells is often restricted to suspension cultures in stirred tank bioreactors. The primary aim of the work reported here was ...
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Article
Perfect fluid space-times with a two-dimensional orthogonally transitive group of homothetic motions
We use theghp formalism to obtain perfect fluid space-times with a two-dimensional and orthogonally transitive group of proper homothetic motionsH 2, with the additional condition that the four-velocity of the fl...
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Article
A class of plane symmetric dust solutions
A class of plane symmetric solutions containing dust is considered. It is argued that, however inhomogeneous the mass distribution, matter on each plane of symmetry has no net attraction to matter on other pla...
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Book reviews
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Book review
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Book
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Evaluation of a Porous Silicone Carrier (Immobasil G) for Animal Cell Culture
Porous carriers can be used in fixed, fluidised and stirred tank perfusion culture systems, where high unit cell density and good scale-up potential can be combined with longterm continuous operation (1 and 2)...
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Chapter
Cultural and physiological factors affecting expression of recombinant proteins
The variability in expression of recombinant proteins has been analyzed with regard to (a) comparison of clones from the same transfection experiment; (b) comparison of the same genetic construct in different ...
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Article
Physical interpretation of vacuum solutions of Einstein's equations. Part II. Time-dependent solutions
The study of interpretations of the vacuum solutions of Einstein's field equations is continued by considering some well known time-dependent solutions. Among these are metrics representing accelerating partic...
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Article
Expression of recombinant antibody and secreted alkaline phosphatase in mammalian cells. Influence of cell line and culture system upon production kinetics
The growth and productivity of an Sp2/0 cell line, F3b10, expressing a recombinant antibody (rAb) and BHK21 cells expressing either the same rAb from the same plasmids (BHK.IgG) or secreted alkaline phosphatas...
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Article
Cultural and physiological factors affecting expression of recombinant proteins
The variability in expression of recombinant proteins has been analyzed with regard to (a) comparison of clones from the same transfection experiment; (b) comparison of the same genetic construct in different ...
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Chapter
Recombinant Antibody Expression in a Fixed Bed Perfusion System
Process parameters affecting the productivity of a fixed bed bioreactor (FBR) system, based on Siran beads, have been studied. A recombinant BHK21 cell line was grown with different combinations of process par...
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Article
Colliding plane gravitational waves with colinear polarization
The colliding plane wave problem is considered using an unconventional coordinate system. This permits a complete solution to be explicitly stated for the general case of arbitrary approaching waves with const...
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Investigation of parameters affecting a fixed bed bioreactor process for recombinant cell lines
A BHK 21 cell line expressing a recombinant antibody was grown in a fixed bed reactor (FBR) system using a porous support made of Siran glass beads. The contribution of five process variables (bead and inoculu...
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Article
Maximisation of perfusion systems and process comparison with batch-type cultures
A comparison of cell yields and monoclonal antibody productivity from the same hybridoma has been made in a wide range of cell bioreactors including both batch and continuous perfusion cultures. The most produ...
