14 Result(s)

Article

On the use of lonafarnib in myelodysplastic syndrome and chronic myelomonocytic leukemia

Lonafarnib is an orally bio-available farnesyltransferase inhibitor that prevents farnesylation of specific target proteins including Ras. In a multicenter study, 67 patients with advanced myelodysplastic synd...

E J Feldman, J Cortes, D J DeAngelo, T Holyoake, B Simonsson, S G O'Brien… in Leukemia (2008)

Article

An amino-acid switch in the BCR-ABL kinase domain modifies sensitivity to imatinib mesylate

T Leguay, V Desplat, V Lagarde, G Marit, J Reiffers, F-X Mahon in Leukemia (2005)

Article

Risk assessment in adult acute lymphoblastic leukaemia before early haemopoietic stem cell transplantation with a geno-identical donor: an easy clinical prognostic score to identify patients who benefit most from allogeneic haemopoietic stem cell transplantation

In 1402 patients allografted in Europe during the period 1990–2000 with an HLA-identical sibling in first remission (CR1), the median interval from CR1 to allotransplant (96 days) was a major prognostic factor...

N-C Gorin, M Labopin, E Polge, C Cordonnier, J P Jouet, M Michallet, D Blaise… in Leukemia (2003)

Article

Higher doses of CD34+ peripheral blood stem cells are associated with increased mortality from chronic graft-versus-host disease after allogeneic HLA-identical sibling transplantation

Allogeneic peripheral blood stem cell transplantation (PBSCT) has emerged as an alternative to bone marrow transplantation. PBSCT can be associated with a higher incidence of chronic graft-versus-host disease ...

M Mohty, K Bilger, E Jourdan, M Kuentz, M Michallet, J H Bourhis, N Milpied… in Leukemia (2003)

Article

Resistance to daunorubicin-induced apoptosis is not completely reversed in CML blast cells by STI571

The leukemogenic property of BCR-ABL in chronic myeloid leukemia (CML) is critically dependent on its protein tyrosine kinase activity. STI571 inhibits the BCR-ABL kinase activity, the growth and the viability...

R Tabrizi, FX Mahon, P Cony Makhoul, V Lagarde, F Lacombe, P Berthaud, JV Melo… in Leukemia (2002)

Article

Results of a phase II trial of a combination of oral cytarabine ocfosfate (YNK01) and interferon α-2b for the treatment of chronic myelogenous leukemia patients in chronic phase

Cytarabine ocfosfate (YNK01) is a prodrug analogue of cytarabine which is resistant to systemic deamination after oral administration. Following initial studies indicating significant anti-tumour activity of Y...

F Maloisel, A Guerci, D Guyotat, N Ifrah, M Michallet, J Reiffers, G Tertain… in Leukemia (2002)

Article

Nitric oxide induces the apoptosis of human BCR-ABL-positive myeloid leukemia cells: evidence for the chelation of intracellular iron

Anti-leukemia activity of human macrophages involves the generation of nitric oxide (NO) derivatives. However, leukemic transformation may involve mechanisms that rescue cells from NO-mediated apoptosis. In th...

H Ferry-Dumazet, M Mamani-Matsuda, M Dupouy, F Belloc, D Thiolat, G Marit… in Leukemia (2002)

Article

Study of apoptosis-related responses of leukemic blast cells to in vitro anthracycline treatment

Anthracyclines trigger an apoptotic cell death but their molecular targets are not totally explored. We investigated the apoptotic response of blast cells and lymphocytes from medullary samples of 31 de novo acut...

M-A Belaud-Rotureau, F Durrieu, G Labroille, F Lacombe, O Fitoussi, P Agape… in Leukemia (2000)

Article

Expression of Flt3-ligand by the endothelial cell

Flt3-ligand (FL) is a cytokine that is of paramount importance in the proliferation of primitive hematopoietic progenitors. In this study, we show that endothelial cells (EC) produce large amounts of soluble F...

A Solanilla, C Grosset, C Lemercier, M Dupouy, FX Mahon, K Schweitzer… in Leukemia (2000)

Article

Factors affecting both peripheral blood progenitor cell mobilization and hematopoietic recovery following autologous blood progenitor cell transplantation in multiple myeloma patients: a monocentric study

The aim of the study was to analyze the factors influencing peripheral blood progenitor cell (PBPC) collection after high-dose cyclophosphamide (HDCYC) (7 g/m²) and hematopoietic recovery after autologous transpl...

G Marit, F Thiessard, C Faberes, P Cony-Makhoul, JM Boiron, P Bernard… in Leukemia (1998)

Article

Endothelial cell support of hematopoiesis is differentially altered by IL-1 and glucocorticoids

We investigated the ability of endothelial cells (EC) to support hematopoiesis in contact and non-contact cocultures with isolated CD34⁺ or CD34⁺/CD38^low cells. In the absence of exogenous cytokines, umbilical ve...

B Jazwiec, A Solanilla, C Grosset, F-X Mahon, M Dupouy, V Pigeonnier-Lagarde… in Leukemia (1998)

Article

Flow cytometry CD45 gating for immunophenoty** of acute myeloid leukemia

A flow cytometry method has been introduced into the routine investigation of whole bone marrow samples following red blood cell lysis on the basis of a primary CD45/side scatter (SSC) gating procedure. Blast ...

F Lacombe, F Durrieu, A Briais, P Dumain, F Belloc, E Bascans, J Reiffers… in Leukemia (1997)

Article

All-trans retinoic acid potentiates the inhibitory effects of interferon α on chronic myeloid leukemia progenitors in vitro

All-trans retinoic acid (ATRA) has recently been shown to synergise with the inhibitory effect of interferon alpha (IFNα) on the growth of malignant cells isolated from solid tumors. We investigated whether ATRA ...

FX Mahon, H Chahine, C Barbot, V Pigeonnier, B Jazwiec, J Reiffers, J Ripoche in Leukemia (1997)

Article

Allogeneic bone marrow transplantation for acute leukemia in patients over the age of 40 years

Extension of allogeneic transplants to older patients has been limited by a high risk of transplant-related death and graft-versus-host disease. To evaluate the feasibility in older patients, a retrospective a...

J-Y Cahn, M Labopin, A Schattenberg, J Reiffers, R Willemze, R Zittoun… in Leukemia (1997)