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A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial
Background/Patients and methods: 16 adult patients with untreated measurable locally advanced or metastatic inoperable soft tissue sarcoma were treated with oral perifosine, a synthetic a...
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Cancer Drugs and Cancer Drug Development for the New Millennium
Most chemotherapeutic agents used today were identified by empirically screening natural products or synthetic compounds for cytotoxic potency in vitro against murine and/or human cancer cell lines and in vivo...