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Article
Open AccessPrognostic implications of abnormalities of chromosome 13 and the presence of multiple cytogenetic high-risk abnormalities in newly diagnosed multiple myeloma
Fluorescence in situ hybridization evaluation is essential for initial risk stratification in multiple myeloma. While the presence of specific cytogenetic high-risk abnormalities (HRA) is known to confer a poor p...
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Article
Open AccessChanges in uninvolved immunoglobulins during induction therapy for newly diagnosed multiple myeloma
Little is known about the impact of multiple myeloma (MM) treatment on uninvolved immunoglobulins (Ig). We identified 448 patients who received high-dose dexamethasone (HD-DEX), lenalidomide and dexamethasone ...
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Article
Open AccessClinical utility of the Revised International Staging System in unselected patients with newly diagnosed and relapsed multiple myeloma
We analyzed the utility of Revised International staging system (RISS) in an unselected cohort of newly diagnosed multiple myeloma (NDMM; cohort 1), and relapsed/refractory multiple myeloma (RRMM; cohort 2) pa...
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Article
Open AccessEvolving changes in disease biomarkers and risk of early progression in smoldering multiple myeloma
We studied 190 patients with smoldering multiple myeloma (SMM) at our institution between 1973 and 2014. Evolving change in monoclonal protein level (eMP) was defined as ⩾10% increase in serum monoclonal prote...
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Article
Open AccessOccurrence and prognostic significance of cytogenetic evolution in patients with multiple myeloma
Cytogenetic evaluation at the time of diagnosis is essential for risk stratification in multiple myeloma, however little is known about the occurrence and prognostic significance of cytogenetic evolution durin...
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Article
Open AccessAbnormal FISH in patients with immunoglobulin light chain amyloidosis is a risk factor for cardiac involvement and for death
Importance of interphase fluorescent in situ hybridization (FISH) with cytoplasmic staining of immunoglobulin FISH (cIg-FISH) on bone marrow is not well understood in light chain amyloidosis (AL). This is in cont...
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Article
Open AccessImprovement in renal function and its impact on survival in patients with newly diagnosed multiple myeloma
Renal impairment (RI) is seen in over a quarter of patients with newly diagnosed multiple myeloma (NDMM). It is not clear if reversal of RI improves the outcome to that expected for NDMM patients without RI. W...
