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Article
Open AccessTargeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis
Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail of autoimmune ther...
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Article
Open AccessClonal diversity predicts persistence of SARS-CoV-2 epitope-specific T-cell response
T cells play a pivotal role in reducing disease severity during SARS-CoV-2 infection and formation of long-term immune memory. We studied 50 COVID-19 convalescent patients and found that T cell response was in...
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Article
Open AccessExploring the pre-immune landscape of antigen-specific T cells
Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells. Using recent advances in immune repertoire sequen...
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Article
Open AccessVDJviz: a versatile browser for immunogenomics data
The repertoire of T- and B-cell receptor sequences encodes the antigen specificity of adaptive immunity system, determines its present state and guides its ability to mount effective response against encounter...
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Article
Open AccesstcR: an R package for T cell receptor repertoire advanced data analysis
The Immunoglobulins (IG) and the T cell receptors (TR) play the key role in antigen recognition during the adaptive immune response. Recent progress in next-generation sequencing technologies has provided an o...
