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  1. No Access

    Chapter

    Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis

    The process of angiogenesis, be it physiological or pathological, requires the coordinated interplay of a variety of vascular growth factor systems. Many preclinical models, and more recently several clinical ...

    Gavin Thurston, Irene Noguera-Troise, Ivan B. Lobov, Christopher Daly… in Angiogenesis (2008)

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    Article

    The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth

    Several recent papers have shown that the Delta-like ligand 4 (Dll4)-Notch system restrains angiogenesis but, paradoxically, Dll4 inhibition decreases tumour growth. Is too much angiogenesis actually a good th...

    Gavin Thurston, Irene Noguera-Troise, George D. Yancopoulos in Nature Reviews Cancer (2007)

  3. No Access

    Article

    Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

    Tumour growth requires accompanying expansion of the host vasculature, with tumour progression often correlated with vascular density. Vascular endothelial growth factor (VEGF) is the best-characterized induce...

    Irene Noguera-Troise, Christopher Daly, Nicholas J. Papadopoulos, Sandra Coetzee… in Nature (2006)