![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Chapter
Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis
The process of angiogenesis, be it physiological or pathological, requires the coordinated interplay of a variety of vascular growth factor systems. Many preclinical models, and more recently several clinical ...
-
Article
The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth
Several recent papers have shown that the Delta-like ligand 4 (Dll4)-Notch system restrains angiogenesis but, paradoxically, Dll4 inhibition decreases tumour growth. Is too much angiogenesis actually a good th...
-
Article
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
Tumour growth requires accompanying expansion of the host vasculature, with tumour progression often correlated with vascular density. Vascular endothelial growth factor (VEGF) is the best-characterized induce...