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  1. No Access

    Article

    Sparse pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction

    A single experimental method alone often fails to provide the resolution, accuracy, and coverage needed to model integral membrane proteins (IMPs). Integrating computation with experimental data is a powerful ...

    Kaitlyn V. Ledwitch, Georg Künze, Jacob R. McKinney… in Journal of Biomolecular NMR (2023)

  2. No Access

    Article

    Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation

    Peptide ligands of class B G-protein-coupled receptors act via a two-step binding process, but the essential mechanisms that link their extracellular binding to intracellular receptor–arrestin interactions are...

    Lisa J. Clark, James Krieger, Alex D. White, Vasyl Bondarenko… in Nature Chemical Biology (2020)

  3. No Access

    Protocol

    Map** of Protein Interfaces in Live Cells Using Genetically Encoded Crosslinkers

    Understanding the topology of protein-protein interactions is a matter of fundamental importance in the biomedical field. Biophysical approaches such as X-ray crystallography and nuclear magnetic resonance can...

    Lisa Seidel, Irene Coin in Noncanonical Amino Acids (2018)