10 Result(s)

Article

Integrative scATAC-seq and scRNA-seq analyses map thymic iNKT cell development and identify Cbfβ for its commitment

Unlike conventional αβT cells, invariant natural killer T (iNKT) cells complete their terminal differentiation to functional iNKT1/2/17 cells in the thymus. However, underlying molecular programs that guide iNKT ...

Jie Wang, Indra Adrianto, Kalpana Subedi, Tingting Liu, **aojun Wu… in Cell Discovery (2023)

Article

Author Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen… in Nature Communications (2023)

Article

Author Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen… in Nature Communications (2022)

Article

Single-cell analysis reveals differences among iNKT cells colonizing peripheral organs and identifies Klf2 as a key gene for iNKT emigration

Invariant natural killer T cell (iNKT) subsets are differentially distributed in various immune organs. However, it remains unclear whether iNKT cells exhibit phenotypical and functional differences in different ...

Jie Wang, Ian Loveless, Indra Adrianto, Tingting Liu, Kalpana Subedi… in Cell Discovery (2022)

Article

Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren’s ...

Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen… in Nature Communications (2022)

Article

Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis

Alveolar macrophages (AMs) derived from embryonic precursors seed the lung before birth and self-maintain locally throughout adulthood, but are regenerated by bone marrow (BM) under stress conditions. However,...

Yi Yao, Que** Liu, Indra Adrianto, **aojun Wu, James Glassbrook… in Nature Communications (2020)

Article

NRG1 variant effects in patients with Hirschsprung disease

Hirschsprung disease (HSCR) is a heterogeneous genetic disorder characterized by absence of ganglion cells along the intestines resulting in functional bowel obstruction. Mutations in neuregulin 1 (NRG1) gene hav...

Gunadi, Nova Yuli Prasetyo Budi, Raman Sethi, Aditya Rifqi Fauzi… in BMC Pediatrics (2018)

Article

Detrimental effects of duplicate reads and low complexity regions on RNA- and ChIP-seq data

Adapter trimming and removal of duplicate reads are common practices in next-generation sequencing pipelines. Sequencing reads ambiguously mapped to repetitive and low complexity regions can also be problemati...

Mikhail G Dozmorov, Indra Adrianto, Cory B Giles, Edmund Glass… in BMC Bioinformatics (2015)

Article

Performance of HLA allele prediction methods in African Americans for class II genes HLA-DRB1, −DQB1, and –DPB1

The expense of human leukocyte antigen (HLA) allele genoty** has motivated the development of imputation methods that use dense single nucleotide polymorphism (SNP) genotype data and the region’s haplotype stru...

Albert M Levin, Indra Adrianto, Indrani Datta, Michael C Iannuzzi… in BMC Genetics (2014)

Chapter and Conference Paper

Active Learning with Support Vector Machines for Tornado Prediction

In this paper, active learning with support vector machines (SVMs) is applied to the problem of tornado prediction. This method is used to predict which storm-scale circulations yield tornadoes based on the ra...

Theodore B. Trafalis, Indra Adrianto… in Computational Science – ICCS 2007 (2007)