10 Result(s)

Article

Correction: Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders

Joanna K. Winstone, Khyatiben V. Pathak, Wendy Winslow… in Journal of Neuroinflammation (2024)

Article

Integrated DNA Methylation/RNA Profiling in Middle Temporal Gyrus of Alzheimer’s Disease

Alzheimer’s disease is a neurodegenerative disorder clinically defined by gradual cognitive impairment and alteration in executive function. We conducted an epigenome-wide association study (EWAS) of a clinica...

Ignazio S. Piras, Danielle Brokaw, Yinfei Kong… in Cellular and Molecular Neurobiology (2023)

Article

Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders

Herbicides are environmental contaminants that have gained much attention due to the potential hazards they pose to human health. Glyphosate, the active ingredient in many commercial herbicides, is the most he...

Joanna K. Winstone, Khyatiben V. Pathak, Wendy Winslow… in Journal of Neuroinflammation (2022)

Article

Identification of retinoblastoma binding protein 7 (Rbbp7) as a mediator against tau acetylation and subsequent neuronal loss in Alzheimer’s disease and related tauopathies

Evidence indicates that tau hyper-phosphorylation and subsequent neurofibrillary tangle formation contribute to the extensive neuronal death in Alzheimer’s disease (AD) and related tauopathies. Recent work has...

Nikhil Dave, Austin S. Vural, Ignazio S. Piras, Wendy Winslow… in Acta Neuropathologica (2021)

Article

Transcriptional profiling of multiple system atrophy cerebellar tissue highlights differences between the parkinsonian and cerebellar sub-types of the disease

Multiple system atrophy (MSA) is a rare adult-onset neurodegenerative disease of unknown cause, with no effective therapeutic options, and no cure. Limited work to date has attempted to characterize the transc...

Ignazio S. Piras, Christiane Bleul… in Acta Neuropathologica Communications (2020)

Article

Epigenomics and transcriptomics analyses of multiple system atrophy brain tissue supports a role for inflammatory processes in disease pathogenesis

Conceição Bettencourt, Ignazio S. Piras… in Acta Neuropathologica Communications (2020)

Article

The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1

Achaete-scute homolog 1 gene (ASCL1) is a gene classifier for the proneural (PN) transcriptional subgroup of glioblastoma (GBM) that has a relevant role in the neuronal-like differentiation of GBM cancer stem cel...

Ashwin Narayanan, Filippo Gagliardi, Alberto L. Gallotti… in Cell Death & Differentiation (2019)

Article

Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer’s Disease and CSF Amyloid Biomarkers in APOE ε4 Non-Carriers

It was recently suggested that beta-site amyloid precursor protein (APP)-cleaving enzyme 2 (BACE2) functions as an amyloid beta (Aβ)-degrading enzyme; in addition to its better understood role as an APP secret...

Matt Huentelman, Matthew De Both, Wayne Jepsen, Ignazio S. Piras… in Scientific Reports (2019)

Article

Correction: Corrigendum: Geographic population structure analysis of worldwide human populations infers their biogeographical origins

Nature Communications 5: Article number: 3513 (2014); Published: 29 April 2016; Updated: 31 October 2016 This article was published without any competing financial interests statement. A revised declaration th...

Eran Elhaik, Tatiana Tatarinova, Dmitri Chebotarev… in Nature Communications (2016)

Article

Geographic population structure analysis of worldwide human populations infers their biogeographical origins

The search for a method that utilizes biological information to predict humans’ place of origin has occupied scientists for millennia. Over the past four decades, scientists have employed genetic data in an ef...

Eran Elhaik, Tatiana Tatarinova, Dmitri Chebotarev… in Nature Communications (2014)