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  1. No Access

    Article

    Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

    Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model. Current preclinical testing regimes for ...

    Richard J. Weaver, Eric A. Blomme, Amy E. Chadwick… in Nature Reviews Drug Discovery (2020)

  2. Article

    Open Access

    Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

    Nrf2 is a key transcriptional regulator of a battery of genes that facilitate phase II/III drug metabolism and defence against oxidative stress. Nrf2 is largely regulated by Keap1, which directs Nrf2 for prote...

    Adam Lister, Taoufik Nedjadi, Neil R Kitteringham, Fiona Campbell… in Molecular Cancer (2011)

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