12 Result(s)

Article

CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis

Progesterone (P₄) is required for the preparation of the endometrium for a successful pregnancy. P₄ resistance is a leading cause of the pathogenesis of endometrial disorders like endometriosis, often leading to ...

Seung Chel Yang, Mira Park, Kwon-Ho Hong, Hyeonwoo La… in Nature Communications (2023)

Article

Dysregulation of T_FH-B-T_RM lymphocyte cooperation is associated with unfavorable anti-PD-1 responses in EGFR-mutant lung cancer

Patients with non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations exhibit an unfavorable response to PD-1 inhibitor through unclear mechanisms. Hypothesizing that EGFR mutati...

Jae-Won Cho, Seyeon Park, Gamin Kim, Heonjong Han, Hyo Sup Shim… in Nature Communications (2021)

Article

White matter tract-specific alterations in patients with primary restless legs syndrome

Prior diffusion tensor imaging (DTI) studies have investigated white matter (WM) changes in patients with primary restless legs syndrome (RLS), but the results were inconsistent. Here, we proposed using tract-...

Hea Ree Park, Hye Ryun Kim, Seunghwan Oh, Joon-Kyung Seong… in Scientific Reports (2021)

Article

Publisher Correction: Overexpression of PVR and PD‑L1 and its association with prognosis in surgically resected squamous cell lung carcinoma

Jii Bum Lee, Min Hee Hong, Seong Yong Park, Sehyun Chae, Daehee Hwang… in Scientific Reports (2021)

Article

Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma

Targeting T-Cell Immunoreceptor with Ig and ITIM domain-poliovirus receptor (PVR) pathway is a potential therapeutic strategy in lung cancer. We analyzed the expression of PVR and programmed death ligand-1 (PD...

Jii Bum Lee, Min Hee Hong, Seong Yong Park, Sehyun Chae, Daehee Hwang… in Scientific Reports (2021)

Article

Intracranial failure after hippocampal-avoidance prophylactic cranial irradiation in limited-stage small-cell lung cancer patients

We evaluated intracranial failure after hippocampus-avoidance-prophylactic cranial irradiation (HA-PCI) for limited-stage small-cell lung cancer (SCLC). Data of 106 patients who received PCI with 25 Gy were re...

Yeona Cho, Joongyo Lee, Ik Jae Lee, Jun Won Kim, Jong Geol Baek… in Scientific Reports (2021)

Article

Peripheral natural killer cells and myeloid-derived suppressor cells correlate with anti-PD-1 responses in non-small cell lung cancer

Inhibition of immune checkpoint proteins like programmed death 1 (PD-1) is a promising therapeutic approach for several cancers, including non-small cell lung cancer (NSCLC). Although PD-1 ligand (PD-L1) expre...

Je-In Youn, Su-Myeong Park, Seyeon Park, Gamin Kim, Hee-Jae Lee… in Scientific Reports (2020)

Article

High CD3 and ICOS and low TIM-3 expression predict favourable survival in resected oesophageal squamous cell carcinoma

With the increasing oncological potential of immunotherapy, several immune checkpoint modulators are being investigated. The value of immune markers, including programmed cell death ligand-1, programmed cell d...

Min Hee Hong, Su-** Shin, Sung Kwan Shin, Dae Joon Kim, Jae Ill Zo… in Scientific Reports (2019)

Article

Patient-Derived Cells to Guide Targeted Therapy for Advanced Lung Adenocarcinoma

Adequate preclinical model and model establishment procedure are required to accelerate translational research in lung cancer. We streamlined a protocol for establishing patient-derived cells (PDC) and identif...

Seok-Young Kim, Ji Yeon Lee, Dong Hwi Kim, Hyeong -Seok Joo… in Scientific Reports (2019)

Article

PD-L1 expression on immune cells, but not on tumor cells, is a favorable prognostic factor for head and neck cancer patients

To investigate the expression of programmed death-ligand 1 (PD-L1) and immune checkpoints and their prognostic value for resected head and neck squamous cell cancer (HNSCC). PD-L1 expression on tumor cells (TC...

Hye Ryun Kim, Sang-Jun Ha, Min Hee Hong, Su ** Heo, Yoon Woo Koh… in Scientific Reports (2016)

Article

Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice

DGCR8 is an RNA-binding protein that interacts with DROSHA to produce pre-microRNA in the nucleus, while DICER generates not only mature microRNA, but also endogenous small interfering RNAs in the cytoplasm. H...

Yeon Sun Kim, Hye-Ryun Kim, Hyongbum Kim, Seung Chel Yang, Mira Park… in Scientific Reports (2016)

Article

Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck

Dacomitinib, an irreversible pan-HER inhibitor, had shown modest clinical activity in squamous cell carcinoma of head and neck (SCCHN) patients. Therefore, validated predictive biomarkers are required to ident...

Kie Kyon Huang, Kang Won Jang, Sangwoo Kim, Han Sang Kim… in Scientific Reports (2016)