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Article

Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells in vitro and in vivo

Osteosarcoma is one of the most malignant neoplasms in adolescents, and it generally develops multidrug resistance. Escin, a natural mixture of triterpene saponins isolated from Aesculus hippocastanum (horse c...

Jian Zhu, Wei Yu, Bing Liu, Yitian Wang, Jianlin shao, Junjie Wang… in Cell Death & Disease (2017)