3,528 Result(s)
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Huimin **ao
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Article
Probing Dual Covalent Irreversible Inhibition of EGFR/FGFR4 by Electrophilic-Based Natural Compounds to Overcome Resistance and Enhance Combination Therapeutic Potentials and Management of Hepatocellular Carcinoma (HCC)
Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the world and accounts for the majority of cases of primary liver cancer. A crucial part of the carcinogenesis of HCC involves aberra...
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Multi-pole ratio single-winding pole-changing permanent magnet motor design and analysis
Pole-changing permanent magnet (PCPM) motors have advantages over traditional permanent magnet synchronous motors (PMSM) in high-speed applications. However, changing the pole number of a motor requires recons...
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The effect of Ti contents on energy storage properties of PLZST antiferroelectric ceramics
The effect of Ti contents on the microstructure, dielectric, and energy storage properties of prepared (Pb0.97La0.02) (Zr0.53Sn0.47)1-xTixO3 (PLZST) antiferroelectric ceramics by a traditional solid-state sinteri...
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Open AccessModulation of dlPFC function and decision-making capacity by repetitive transcranial magnetic stimulation in methamphetamine use disorder
This study explores the impact of repetitive transcranial magnetic stimulation (rTMS) on decision-making capabilities in individuals with methamphetamine use disorder (MUD), alongside potential underlying psyc...
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Open AccessB-cell hub genes play a cardiovascular pathogenic role of in childhood obesity and Kawasaki disease as revealed by transcriptomics-based analyses
The study aims to explore the central genes that Kawasaki disease (KD) and Obesity (OB) may jointly contribute to coronary artery disease. Investigating single-cell datasets (GSE168732 and GSE163830) from a co...
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Open AccessAssociations of metabolic changes and polygenic risk scores with cardiovascular outcomes and all-cause mortality across BMI categories: a prospective cohort study
Associations between metabolic status and metabolic changes with the risk of cardiovascular outcomes have been reported. However, the role of genetic susceptibility underlying these associations remains unexpl...
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Open AccessEfficacy of acupuncture in refractory irritable bowel syndrome patients: a randomized controlled trial
Previous studies have confirmed that acupuncture for irritable bowel syndrome (IBS) provided an additional benefit over usual care alone. Therefore, we performed a multicenter, randomized, sham-controlled tria...
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Study on dimensional stability of fiberboard and its products in hygrothermal environments
In this paper, a dynamic vapor sorption analyzer in conjunction with the Dino-Lite Edge Digital Microscope was utilized to study the moisture sorption and thickness variation characteristics of the surface and...
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Article
Open AccessZnO NPs induce miR-342-5p mediated ferroptosis of spermatocytes through the NF-κB pathway in mice
Zinc oxide nanoparticle (ZnO NP) is one of the metal nanomaterials with extensive use in many fields such as feed additive and textile, which is an emerging threat to human health due to widely distributed in ...
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Author Correction: High-yield porphyrin production through metabolic engineering and biocatalysis
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Tracking-seq reveals the heterogeneity of off-target effects in CRISPR–Cas9-mediated genome editing
The continued development of novel genome editors calls for a universal method to analyze their off-target effects. Here we describe a versatile method, called Tracking-seq, for in situ identification of off-t...
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Clinical prognostic value of different NPM1 mutations in acute myeloid leukemia patients
Background: Acute myeloid leukemia (AML) patients with various nucleophosmin 1 (NPM1) mutations are controversial in the prognosis. This study aimed to investigate the prognosis of patie...
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Deep-sea visual dataset of the South China sea
The deep sea has abundant resources and is regarded as the “sixth continent” that humans can use. Although research on the deep sea has made some progress, its exploration is not deep enough. The acquisition a...
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Comparison of novel PSMA-targeting [177Lu]Lu-P17-087 with its albumin binding derivative [177Lu]Lu-P17-088 in metastatic castration-resistant prostate cancer patients: a first-in-human study
Prostate-specific membrane antigen (PSMA) is a promising target for diagnosis and radioligand therapy (RLT) of prostate cancer. Two novel PSMA-targeting radionuclide therapy agents, [177Lu]Lu-P17-087, and its alb...
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Article
Masting promotes transformation from predation to mutualism in an oak-weevil-rodent system
The significance of ecological non-monotonicity (a function whose first derivative changes signs) in sha** the structure and functions of the ecosystem has recently been recognized, but such studies involvin...
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Open AccessThe predictive value of GLIM criteria on clinical outcomes and responses to nutritional support in patients with neurocritical illnesses
Neurocritically ill patients frequently exhibit coma, gastroparesis, and intense catabolism, leading to an increased risk of malnutrition. The Global Leadership Initiative on Malnutrition (GLIM) criteria for t...
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Open AccessCardiac-derived extracellular vesicles improve mitochondrial function to protect the heart against ischemia/reperfusion injury by delivering ATP5a1
Numerous studies have confirmed the involvement of extracellular vesicles (EVs) in various physiological processes, including cellular death and tissue damage. Recently, we reported that EVs derived from ische...
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Projections and uncertainty analysis of socioeconomic exposure to compound dry and hot events under 1.5℃ and 2.0℃ warming levels across China
Climate change is expected to intensify compound dry and hot events (CDHEs) in China, exacerbating socioeconomic exposure to CDHEs. Based on 23 global climate models (GCMs) data from Coupled Model Intercompari...
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Identification and characterization of four novel xiaomi alleles to facilitate foxtail millet as a C4 model plant
A diverse genetic background is essential for genetic analysis and functional genomics research in model plants. In this study, four novel xiaomi-like mutants in different genetic backgrounds, named xiaomi3, xiao...
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XPO1 inhibition displays anti-leukemia efficacy against DNMT3A-mutant acute myeloid leukemia via downregulating glutathione pathway
Acute myeloid leukemia (AML) patients with DNA methyltransferase 3A (DNMT3A) mutation display poor prognosis, and targeted therapy is not available currently. Our previous study identified increased expression...
