34 Result(s)
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Hui**g Chen
Microbial Genetics and Genomics
Plant Genetics and Genomics
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Article
Open AccessThe performance of homopolymer detection using dichromatic and tetrachromatic fluorogenic next-generation sequencing platforms
Homopolymer (HP) sequencing is error-prone in next-generation sequencing (NGS) assays, and may induce false insertion/deletions and substitutions. This study aimed to evaluate the performance of dichromatic an...
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Open AccessCharacterization and mitigation of artifacts derived from NGS library preparation due to structure-specific sequences in the human genome
Hybridization capture-based targeted next generation sequencing (NGS) is gaining importance in routine cancer clinical practice. DNA library preparation is a fundamental step to produce high-quality sequencing...
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Open AccessDKC1 aggravates gastric cancer cell migration and invasion through up-regulating the expression of TNFAIP6
Gastric cancer (GC) is one hackneyed malignancy tumor accompanied by high death rate. DKC1 has been discovered to serve as a facilitator in several cancers. Additionally, it was discovered from one study that ...
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Open AccessQuartet DNA reference materials and datasets for comprehensively evaluating germline variant calling performance
Genomic DNA reference materials are widely recognized as essential for ensuring data quality in omics research. However, relying solely on reference datasets to evaluate the accuracy of variant calling results...
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Open AccessWhole-genome and dispersed duplication, including transposed duplication, jointly advance the evolution of TLP genes in seven representative Poaceae lineages
In the evolutionary study of gene families, exploring the duplication mechanisms of gene families helps researchers understand their evolutionary history. The tubby-like protein (TLP) family is essential for g...
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Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage
The current pandemic of coronavirus disease 2019 (COVID-19), transmitted person-to-person by the severe acute respiratory syndrome of coronavirus 2 (SARS-CoV-2), poses a threat to global public health.
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Open AccessVisProDom: an interactive Shiny/R application for displaying protein domains with transcriptional features
Both the protein domains and transcript structures influence protein functional variation. The genomic location of both protein domains and transcript structural features can be described using the genomic coo...
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FNC inhibits non-small cell lung cancer by activating the mitochondrial apoptosis pathway
Previously, we published that 4′-azid-2′-deoxy-2′-fluorarabinoside (FNC), a novel cytosine nucleoside analog, has good anti-viral and anti-tumor activity.
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Open AccessGenomic analysis of SBP gene family in Saccharum spontaneum reveals their association with vegetative and reproductive development
SQUAMOSA promoter binding proteins (SBPs) genes encode a family of plant-specific transcription factors involved in various growth and development processes, including flower and fruit development, leaf initiatio...
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Open AccessAuthor Correction: Chromatin lncRNA Platr10 controls stem cell pluripotency by coordinating an intrachromosomal regulatory network
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Open AccessChromatin lncRNA Platr10 controls stem cell pluripotency by coordinating an intrachromosomal regulatory network
A specific 3-dimensional intrachromosomal architecture of core stem cell factor genes is required to reprogram a somatic cell into pluripotency. As little is known about the epigenetic readers that orchestrate...
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Open AccessIdentification and allele mining of new candidate genes underlying rice grain weight and grain shape by genome-wide association study
Grain weight and grain shape are important agronomic traits that affect the grain yield potential and grain quality of rice. Both grain weight and grain shape are controlled by multiple genes. The 3,000 Rice G...
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Open AccessEvolutionary research on the expansin protein family during the plant transition to land provides new insights into the development of Tartary buckwheat fruit
Plant transitions to land require robust cell walls for regulatory adaptations and to resist changing environments. Cell walls provide essential plasticity for plant cell division and defense, which are often ...
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Open AccessGenetic analysis of rice seedling traits related to machine transplanting under different seeding densities
Due to the diversity of rice varieties and crop** systems in China, the limitation of seeding density and seedling quality makes it hard to improve machine-transplanted efficiency. Previous studies have show...
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Abnormally expressed lncRNAs in the prognosis and clinicopathology of oesophageal cancer: a systematic review and meta-analysis
The relationship between the long noncoding RNA (lncRNA) expression and oesophageal cancer prognosis has been widely studied, but less consensus has been reached. We conducted this study to evaluate the relati...
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Open AccessAssessment of computational methods for the analysis of single-cell ATAC-seq data
Recent innovations in single-cell Assay for Transposase Accessible Chromatin using sequencing (scATAC-seq) enable profiling of the epigenetic landscape of thousands of individual cells. scATAC-seq data analysi...
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Open AccessGenome-wide investigation of the heat shock transcription factor (Hsf) gene family in Tartary buckwheat (Fagopyrum tataricum)
Heat shock transcription factor (Hsfs) is widely found in eukaryotes and prokaryotes. Hsfs can not only help organisms resist high temperature, but also participate in the regulation of plant growth and develo...
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Transcriptome-wide identification and characterization of microRNAs responsive to phosphate starvation in Populus tomentosa
miRNAs (microRNAs) are ~ 21-nt non-coding small RNAs (sRNAs) that play crucial regulatory roles in plant biotic and abiotic stress responses. Phosphorus (Pi) deficiency constrains plant growth and reduces yiel...
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Transcriptome-wide identification of miRNA targets and a TAS3-homologous gene in Populus by degradome sequencing
Degradome sequencing has been applied to identify miRNA-directed mRNA cleavage and understand the biological function of miRNAs and their target genes in plants defense to stress. miRNAs involved in the respon...
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Open AccessGenome-wide identification, phylogeny, evolutionary expansion and expression analyses of bZIP transcription factor family in tartary buckwheat
In reported plants, the bZIP family is one of the largest transcription factor families. bZIP genes play roles in the light signal, seed maturation, flower development, cell elongation, seed accumulation protein,...
