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Article
Open AccessDevelopment and validation of a nomogram model of depression and sleep disorders and the risk of disease progression in patients with breast cancer
In this study, we investigated the relationship between the risk of postoperative progressive disease (PD) in breast cancer and depression and sleep disorders in order to develop and validate a suitable risk p...
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Article
Open AccessPI3K/AKT/mTOR signaling pathway: an important driver and therapeutic target in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a highly heterogeneous tumor lacking estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. It has higher ag...
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Article
Salvage haploidentical transplantation for graft failure after first haploidentical allogeneic stem cell transplantation: an updated experience
Graft failure is a fatal complication following allogeneic stem cell transplantation where a second transplantation is usually required for salvage. However, there are no recommended regimens for second transp...
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Article
Open AccessClinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma
Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data sh...
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Article
Open AccessLiquid-based cytology specimens for next-generation sequencing in lung adenocarcinoma: challenges and evaluation of targeted therapy
To explore challenges of liquid-based cytology (LBC) specimens for next-generation sequencing (NGS) in lung adenocarcinoma and evaluate the efficacy of targeted therapy.
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Article
One-neutron strip** process in the 209Bi(6Li, 5Li)210Bi* reaction reaction
One-neutron strip** process between \(^{6}\) 6 ...
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Article
Open AccessDysregulated RNA editing of EIF2AK2 in polycystic ovary syndrome: clinical relevance and functional implications
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive ages. Our previous study has implicated a possible link between RNA editing and PCOS, yet the actual role of R...
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Article
Open AccessA multicenter prospective study on the management of hepatoblastoma in children: a report from the Chinese Children’s Cancer Group
This study aimed to identify survival risk factors in Chinese children with hepatoblastoma (HB) and assess the effectiveness of the new treatment protocol proposed by the Chinese Children’s Cancer Group (CCCG)...
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Article
Controlling hydrogenation of C=C and C=O bonds in cinnamaldehyde using Pt1/Ni and Pt1/Co single-atom alloy catalysts
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Article
Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway
The angiotensin II type 2 receptor (AT2R) is a well-established component of the renin-angiotensin system and is known to counteract classical activation of this system and protect against organ damage. Pharma...
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Article
Controlling factors of heavy metal(loid) accumulation in rice: Main and interactive effects
Identifying the key determinants of heavy metal(loid) accumulation in rice and quantifying their contributions are critical for precise prediction of heavy metal(loid) concentrations in rice and the formulatio...
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Article
Open AccessProteinase 3 depletion attenuates leukemia by promoting myeloid differentiation
Hematopoietic stem and progenitor cells (HSPCs) that have impaired differentiation can transform into leukemic blasts. However, the mechanism that controls differentiation remains elusive. Here, we show that t...
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Article
Open AccessZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression
Post-translational modifications of proteins in malignant transformation and tumor maintenance of pancreatic ductal adenocarcinoma (PDAC) in the context of KRAS signaling remain poorly understood. Here, we use th...
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Article
Open AccessBreak down the decentralization-security-privacy trilemma in management of distributed energy systems
Distributed energy systems encompass a diverse range of generation and storage solutions on the user side, where decentralized management schemes to maximize the overall social welfare are preferred considerin...
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Article
Open AccessCOVID-19 was associated with the complications after allogeneic hematopoietic stem cell transplantation
We aimed to identify the severity and duration of COVID-19 infection on complications after allo-HSCT. Enrolled 179 hospitalized patients with COVID-19 were categorized into long-term infection (> 18 days, n = 90...
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Article
Open AccessIntegrated analysis reveals critical cisplatin-resistance regulators E2F7 contributed to tumor progression and metastasis in lung adenocarcinoma
Drug resistance poses a significant challenge in cancer treatment, particularly as a leading cause of therapy failure. Cisplatin, the primary drug for lung adenocarcinoma (LUAD) chemotherapy, shows effective t...
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Article
Transcriptome Analysis Reveals Dynamic Microglial-Induced A1 Astrocyte Reactivity via C3/C3aR/NF-κB Signaling After Ischemic Stroke
Microglia and astrocytes are key players in neuroinflammation and ischemic stroke. A1 astrocytes are a subtype of astrocytes that are extremely neurotoxic and quickly kill neurons. Although the detrimental A1 ...
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Article
Promoter replication of grape MYB transcription factor is associated with a new red flesh phenotype
In our study, we discovered a fragment duplication autoregulation mechanism in ‘ZS-HY’, which may be the reason for the phenotype of red foliage and red flesh in grapes.
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Article
Wheel-legged In-pipe Robot with a Bioinspired Hook and Dry Adhesive Attachment Device
In-pipe robots have been widely used in pipes–with smooth inner walls. However, current in-pipe robots face challenges in terms of moving past obstacles and climbing in marine-vessel pipeline systems, which ar...
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Article
Double-confined nanoheterostructure Sb/Sb2S3@Ti3C2Tx@C toward ultra-stable Li-/Na-ion batteries
Antimony-based materials with high capacities and moderate potentials are promising anodes for lithium-/sodium-ion batteries. However, their tremendous volume expansion and inferior conductivity lead to poor s...
