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Article
Optical and electrical anisotropy regulation engineering of low-dimensional materials toward polarized detection and imaging applications
Polarized-sensitive image sensors are a kind of photodetector with great development potential due to their enhanced ability to detect and identify the target objects from the aspect of spatial, spectral and p...
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Article
Open AccessIdentifying and Extracting Rare Diseases and Their Phenotypes with Large Language Models
Phenoty** is critical for informing rare disease diagnosis and treatment, but disease phenotypes are often embedded in unstructured text. While natural language processing (NLP) can automate extraction, a ma...
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Article
Prompt Tuning in Biomedical Relation Extraction
Biomedical relation extraction (RE) is critical in constructing high-quality knowledge graphs and databases as well as supporting many downstream text mining applications. This paper explores prompt tuning on ...
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Article
Fruquintinib plus paclitaxel versus placebo plus paclitaxel for gastric or gastroesophageal junction adenocarcinoma: the randomized phase 3 FRUTIGA trial
The vascular endothelial growth factor pathway plays a key role in the pathogenesis of gastric cancer. In the multicenter, double-blind phase 3 FRUTIGA trial, 703 patients with advanced gastric or gastroesopha...
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Article
Open AccessIGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease with an unknown etiology. RA cannot be fully cured and requires lengthy treatment, imposing a significant burden on both individuals and society. Due t...
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Article
Open AccessClinical practice guidelines for esophagogastric junction cancer: Upper GI Oncology Summit 2023
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Article
Application of 18β-glycyrrhetinic acid in the structural modification of natural products: a review
18β-Glycyrrhetinic acid (GA) is an oleane-type pentacyclic triterpene saponin obtained from glycyrrhizic acid by removing 2 glucuronic acid groups. GA and its analogues are active substances of glycyrrhiza aic...
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Article
Open AccessRepurposing non-pharmacological interventions for Alzheimer's disease through link prediction on biomedical literature
Non-pharmaceutical interventions (NPI) have great potential to improve cognitive function but limited investigation to discover NPI repurposing for Alzheimer's Disease (AD). This is the first study to develop ...
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Article
Artificial intelligence learning platform in a visual programming environment: exploring an artificial intelligence learning model
Amidst the rapid advancement in the application of artificial intelligence learning, questions regarding the evaluation of students’ learning status and how students without relevant learning foundation on thi...
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Article
Displacement and stress pattern-based thickness recommendation of seismic buffers for depth ranges of a circular rock tunnel
The extent and forms of seismic damage vary with the tunnel depth range, according to which seismic measures should be designed. A seismic buffer of expanded polystyrene geofoam that is widely applied in retai...
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Article
Efficacy comparison of 21 interventions to prevent retinopathy of prematurity: a Bayesian network meta-analysis of randomized controlled trials
The objective of this study was to evaluate the comparative efficacy of current interventions for the prevention of retinopathy of prematurity (ROP) in premature infants.
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Article
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial
Epigenetic modifications of chromatin, including histone acetylation, and tumor angiogenesis play pivotal roles in creating an immunosuppressive tumor microenvironment. In the randomized phase 2 CAPability-01 ...
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Article
Novel intelligent reasoning system for tool wear prediction and parameter optimization in intelligent milling
Accurate intelligent reasoning systems are vital for intelligent manufacturing. In this study, a new intelligent reasoning system was developed for milling processes to accurately predict tool wear and dynamic...
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Article
Divinyl sulfone, an oxidative metabolite of sulfur mustard, induces caspase-independent pyroptosis in hepatocytes
Sulfur mustard (SM) is a highly toxic blister agent which has been used many times in several wars and conflicts and caused heavy casualties. Ease of production and lack of effective therapies make SM a potent...
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Article
Information undergraduate and non-information undergraduate on an artificial intelligence learning platform: an artificial intelligence assessment model using PLS-SEM analysis
Artificial intelligence (AI) education is becoming an advanced learning trend in programming education. However, AI subjects can be difficult to understand because they require high programming skills and comp...
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Article
Author Correction: Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial
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Article
Risk factors for acute kidney injury in pediatric patients after hematopoietic stem cell transplantation: a systematic review and meta-analysis
Risk factors for acute kidney injury (AKI) in pediatric patients after hematopoietic stem cell transplantation (HSCT) remain controversial.
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Article
Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial
Perioperative chemotherapy is the standard treatment for locally advanced gastric or gastro-esophageal junction cancer, and the addition of programmed cell death 1 (PD-1) inhibitor is under investigation. In t...
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Article
Open AccessEndoplasmic reticulum aminopeptidase 2 regulates CD4+ T cells pyroptosis in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease with a complex pathogenesis that has not yet been fully elucidated, and T-cell pyroptosis is an important pathogenetic factor in RA. This ...
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Article
Open AccessRapid and visual identification of β-lactamase subtypes for precision antibiotic therapy
The abuse of antibiotics urgently requires rapid identification of drug-resistant bacteria at the point of care (POC). Here we report a visual paper sensor that allows rapid (0.25-3 h) discrimination of the su...
