-
Article
Open Access„Virtual reality perimetry“ und „home perimetry“
Im vorliegenden Artikel sollen auf „virtual reality“ (VR) basierende Verfahren zur „home perimetry“ (HP) beschrieben werden, und es soll ein Überblick darüber gegeben werden, welche Verfahren bereits heute ein...
-
Article
Open AccessA distinct dimer configuration of a diatom Get3 forming a tetrameric complex with its tail-anchored membrane cargo
Most tail-anchored (TA) membrane proteins are delivered to the endoplasmic reticulum through a conserved posttranslational pathway. Although core mechanisms underlying the targeting and insertion of TA protein...
-
Article
Open AccessEfficacy and safety of tepotinib in Asian patients with advanced NSCLC with MET exon 14 skip** enrolled in VISION
Tepotinib, a MET inhibitor approved for the treatment of MET exon 14 (METex14) skip** NSCLC, demonstrated durable clinical activity in VISION (Cohort A + C; N = 313): objective response rate (ORR) 51.4% (95% CI...
-
Article
Open AccessLong-term complications and outcomes of augmentation cystoplasty in children with neurogenic bladder
Augmentation cystoplasty (AC) is an effective surgical procedure for patients with neurogenic bladder whenever conservative treatments have failed. The present study aimed to determine the risks of metabolic c...
-
Article
Simulations on time-dependent behaviour based on wall deflection of deep excavations in Jakarta
Finite element analyses were conducted on two prominent cases of large-scale deep excavation in Central Jakarta, Indonesia. Large lateral wall deflections were observed during the final excavation stage, presu...
-
Article
Open AccessEvaluation of combination treatment with DS-1205c, an AXL kinase inhibitor, and osimertinib in metastatic or unresectable EGFR-mutant non-small cell lung cancer: results from a multicenter, open-label phase 1 study
The objective of this study was to evaluate the safety and tolerability of DS-1205c, an oral AXL-receptor inhibitor, in combination with osimertinib in metastatic or unresectable EFGR-mutant non-small cell lung c...
-
Article
Open AccessThe revealing of a novel lipid transfer protein lineage in green algae
Non-specific lipid transfer proteins (nsLTPs) are a group of small and basic proteins that can bind and transfer various lipid molecules to the apoplastic space. A typical nsLTP carries a conserved architectur...
-
Article
Open AccessProton pump inhibitors reduce the survival of advanced lung cancer patients with therapy of gefitinib or erlotinib
Gefitinib and erlotinib are the first-line tyrosine kinase inhibitors (TKI) for advanced non-small-cell lung cancer. However, co-administration of either drug with proton pump inhibitors (PPI) or histamine-2 r...
-
Article
Open AccessPrognostic impact of angiotensin-converting enzyme inhibitors and angiotensin receptors blockers in esophageal or gastric cancer patients with hypertension - a real-world study
Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are used in treating cardiovascular diseases. Previous studies indicated that ACEIs/ARBs may benefit cancer patients by...
-
Article
Effectiveness of “OralDETECT”: a Repetitive Test-enhanced, Corrective Feedback Method Competency Assessment Tool for Early Detection of Oral Cancer
Early diagnosis of oral cancer results in less aggressive treatment and improves the quality of life and overall 5-year survival rate. Well-trained dental professionals can play a crucial role in the early det...
-
Article
Open AccessSurvival outcomes of management in metastatic gastric adenocarcinoma patients
Chemotherapy is generally considered as the main treatment for metastatic gastric adenocarcinoma. The role of gastrectomy for metastatic gastric cancer without obvious symptoms is controversial. The objective ...
-
Article
Transition metal dichalcogenides to optimize the performance of peptide-imprinted conductive polymers as electrochemical sensors
Molecularly imprinted polymer (MIP)-based electrochemical sensors for the protein α-synuclein (a marker for Parkinson’s disease) were developed using a peptide epitope from the protein. MIPs doped with various...
-
Article
Open AccessEffects of hearing impairment and hearing aid use on the incidence of cognitive impairment among community-dwelling older adults: evidence from the Taiwan Longitudinal Study on Aging (TLSA)
Previous studies have reported associations between hearing impairment (HI) and cognitive impairment, but the evidence is not conclusive while considering concurrent geriatric syndromes. Especially, evidence f...
-
Article
Repurposing Ophthalmologic Timolol for Dermatologic Use: Caveats and Historical Review of Adverse Events
Ophthalmic timolol solution is increasingly being repurposed as a topical therapeutic for a variety of dermatologic diseases, including pyogenic granulomas, infantile hemangiomas, and chronic wounds. There are...
-
Article
Sustainable Characteristics of Reinforced Soil Structures – from Ancient Great Walls to Modern GRS Walls
This paper is dedicated to the memory of the Late Dr. Jonathan T.H. Wu in recognition of his outstanding contribution to the field of reinforced soil structures, especially for the geosynthetic-reinforced soil...
-
Article
Large paleo-rockslide induced by buckling failure at Jiasian in Southern Taiwan
The major regions of Taiwan consist of high-relief terrain exposed to frequent typhoons and earthquakes. Recently, thousands of potential large-scale landslides have been delineated via remote sensing analysis...
-
Article
Open AccessA phase I study of pexidartinib, a colony-stimulating factor 1 receptor inhibitor, in Asian patients with advanced solid tumors
Background Pexidartinib, a novel, orally administered small-molecule tyrosine kinase inhibitor, has strong selectivity against colony-stimulating factor 1 receptor. This phase I, nonrandomized, open-label multipl...
-
Chapter and Conference Paper
A Reversible Information Hiding Scheme Based on Index Encryption Strategy in VQ-Image
In 2017, Yan et al. proposed a method of image cryptosystem based on VQ and cross chaotic map. In their method, they applied index table to swap the index with randomization as the method of image cryptosystem...
-
Article
Open AccessOxytocin maintains lung histological and functional integrity to confer protection in heat stroke
Oxytocin (OT) has been reported to have a protective effect in lipopolysaccharide-induced experimental acute lung injury (ALI). However, its role in heat stroke-related ALI has never been investigated. Herein,...
-
Chapter and Conference Paper
Experimental Investigation of Cross-Laminated Timber Shear Wall Under Shear Force by Using Digital Image Correlation Method
At the beginning of the 20th century, a new wood manufacturing technology, i.e. cross-laminated timber (CLT), was started. In Taiwan, the manufacturing technology of CLT has just started recently. For the sake o...
