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  1. No Access

    Article

    A New Statistical Method for Dose-Finding Based on Efficacy and Toxicity in Early Phase Clinical Trials

    Most statistical methods for dose-finding in phase I clinical trials determine a maximum tolerable dose based on toxicity while ignoring efficacy. Most phase II designs assume that an acceptable dose has been ...

    Peter F. Thall, Elihu H. Estey, Hsi-Guang Sung in Investigational New Drugs (1999)

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    Chapter

    Biology-driven Clustering of Microarray Data

    In this note, we describe an approach to the analysis of microarray data that uses significant biological information early in the process. By combining information about the biological function and chromosoma...

    Kevin R. Coombes, Keith A. Baggerly… in Methods of Microarray Data Analysis II (2002)

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    Chapter and Conference Paper

    Multi-Course Treatment Strategies for Clinical Trials of Rapidly Fatal Diseases

    Therapy of rapidly fatal diseases often requires multiple courses of treatment. In each course, the treatment may achieve the desired clinical goal, “response,” the patient may survive without response, “failu...

    Peter F. Thall, Hsi-Guang Sung, Elihu H. Estey in Case Studies in Bayesian Statistics (2002)